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A kind of medical polyetheretherketone composite material and preparation method thereof

A polyetheretherketone and composite material technology, which is applied in the field of medical materials, can solve the problems of reducing mechanical properties, biological activity and poor mechanical properties, and achieves the effects of reducing influence, simple preparation method and good biological activity.

Active Publication Date: 2020-11-24
成都普特斯医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the defects of poor biological activity and mechanical properties of the existing PEEK-HAP complex, and provide a medical polyether ether ketone composite material and its preparation method; the present invention treats hydroxyapatite by polyamino acid The micro-crosslinking modification of polyether ether ketone with polyvinyl alcohol makes the composite material without significantly reducing the mechanical properties, and the amount of hydroxyapatite added is larger. The orthopedic implant made of the composite material has Better biological activity and mechanical properties have a positive effect on solving clinical problems of implants in medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Dissolve 3 parts of polyamino acid with a degree of polymerization of 12 into water to form a solution, mix with 40 parts of hydroxyapatite with a particle size of 1 μm and react at a temperature of 70 ° C for 1.5 hours. After the reaction is completed to dry;

[0029] (2) Mix the treated hydroxyapatite in step (1) with 50 parts of polyether ether ketone with a degree of polymerization of 200, 4 parts of polyvinyl alcohol with a degree of polymerization of 400, and 3 parts of polyurethane to obtain a mixed material;

[0030] (3) Cross-linking and extruding the mixture with a twin-screw extruder to obtain a medical polyether ether ketone composite material.

Embodiment 2

[0032] (1) Dissolve 2 parts of polyamino acid with a degree of polymerization of 5 into water to form a solution, then mix with 45 parts of hydroxyapatite with a particle size of 0.01 μm and react at 80°C for 0.5h, and the reaction is complete after drying;

[0033](2) Mix the treated hydroxyapatite in step (1) with 55 parts of polyether ether ketone with a polymerization degree of 250, 3-6 parts of polyvinyl alcohol with a polymerization degree of 500, and 2 parts of polyurethane get the mixture;

[0034] (3) Cross-linking and extruding the mixture with a twin-screw extruder to obtain a medical polyether ether ketone composite material.

Embodiment 3

[0036] (1) Dissolve 5 parts of polyamino acid with a degree of polymerization of 20 into water to form a solution, mix with 30 parts of hydroxyapatite with a particle size of 10 μm, and react at 60°C for 3 hours. After the reaction is completed, carry out dry;

[0037] (2) Mix the treated hydroxyapatite in step (1) with 45 parts of polyether ether ketone with a degree of polymerization of 120, 3-6 parts of polyvinyl alcohol with a degree of polymerization of 300, and 5 parts of polyurethane get the mixture;

[0038] (3) Cross-linking and extruding the mixture with a twin-screw extruder to obtain a medical polyether ether ketone composite material.

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Abstract

The invention discloses a medicinal polyether-ether-ketone composite material and a preparation method thereof. The medicinal polyether-ether-ketone composite material is prepared from the following raw materials in parts by weight: 45-55 parts of polyether-ether-ketone, 30-45 parts of hydroxyapatite, 3-6 parts of polyvinyl alcohol, 2-5 parts of polyurethane and 2-5 parts of polyamino acid. On premise that the hydroxyapatite is treated with the polyamino acid, the polyether-ether-ketone is subjected to micro-crosslinking modification with the polyvinyl alcohol, and the mechanical properties ofthe composite material are not remarkably degraded, a relatively great deal of the hydroxyapatite needs to be added; an orthopedic implant made of the composite material is relatively good in bioactivity and mechanical property, and the composite material has the beneficial effects in solving clinical problems of medical implants.

Description

technical field [0001] The invention relates to the field of medical materials, in particular to a medical polyether ether ketone composite material and a preparation method thereof. Background technique [0002] As orthopedic implants made of different materials are widely used in clinical practice, people have a clearer understanding of the performance of various materials in biological tissues: traditional materials (such as cobalt chromium alloy, titanium, stainless steel, etc.) Orthopedic implants have a much higher elastic modulus than bone, but their biocompatibility is poor; while orthopedic implants made of polymers have good biocompatibility, they cannot withstand physiological loads and cannot As long-term load-bearing implants, the development of biological materials whose structure and mechanical properties match those of bone is the key to solving the above clinical problems. [0003] The elastic modulus of polyetheretherketone (PEEK) is close to that of corti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L61/16C08L29/04C08L75/04C08L77/00C08K3/32
CPCC08K2201/003C08L61/16C08L2203/02C08L2205/035C08L29/04C08L75/04C08L77/00C08K3/32
Inventor 洪艳袁迎春
Owner 成都普特斯医疗科技有限公司