Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of ultrathin-walled chitosan microcapsule and preparation method thereof

A chitosan and ultra-thin-wall technology is applied in the field of chitosan microcapsule preparation, which can solve the problems of complex operation, poor stability, complex structure, etc., and achieve the effects of good appearance, improved safety and good stability.

Active Publication Date: 2020-06-30
四川迈可隆生物科技有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The commonly used preparation methods of ultra-thin-walled chitosan microcapsules include template self-assembly method and template coating method. These methods all need to remove the template through subsequent processing, and the operation steps are relatively cumbersome.
In addition, the formation of the capsule wall in these methods often relies on electrostatic interaction or hydrogen bonding, which is less stable than the microcapsule wall prepared by covalent bond crosslinking.
Due to the limitations of deposition times and template size, the size of microcapsules produced by template self-assembly and template coating methods generally does not exceed 100 μm, and the thickness of the capsule wall is generally in the range of tens to tens of nanometers, which limit the size of chitosan microcapsules. usage of
[0004] Through the microfluidic O / W / O double emulsion template method, the chitosan microcapsules with complete structure and good mechanical strength can be obtained by cross-linking the middle water layer with small organic molecules, but this method requires two stages with a relatively complex structure. The microfluidic device is complicated to operate, and the wall thickness of the prepared chitosan microcapsules is more than 100nm, so it is impossible to prepare ultra-thin wall chitosan microcapsules
CN102626602A discloses a method for preparing chitosan microcapsules with a water-in-oil single emulsion as a template. Although the method is simpler than the microfluidic O / W / O double emulsion template method, the method prepared The wall thickness of chitosan microcapsules is more than hundreds of nanometers, and it is still impossible to make ultra-thin-walled chitosan microcapsules

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of ultrathin-walled chitosan microcapsule and preparation method thereof
  • A kind of ultrathin-walled chitosan microcapsule and preparation method thereof
  • A kind of ultrathin-walled chitosan microcapsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] In the present embodiment, the ultrathin-walled chitosan microcapsules are prepared, and the steps are as follows:

[0058] (1) Preparation of dispersed phase and continuous phase fluid

[0059] Prepare the dispersed phase fluid: add terephthalaldehyde into the soybean oil at room temperature, stir well until the terephthalaldehyde dissolves in the soybean oil to obtain the dispersed phase fluid, the concentration of terephthalaldehyde in the dispersed phase fluid is 0.0075g / mL;

[0060] Preparation of continuous phase fluid: at room temperature, water-soluble chitosan with a deacetylation degree of 85%, a weight average molecular weight Mw≤5000g / mol, and hydroxyethyl cellulose with a weight average molecular weight Mw=500000g / mol were added to deionized water , fully stirred until dissolved, then adjust the pH value to 6.4 with 1mol / L NaOH solution to obtain the continuous phase fluid, in the continuous phase fluid, the concentration of water-soluble chitosan is 0.02...

Embodiment 2

[0075] In the present embodiment, the ultrathin-walled chitosan microcapsules are prepared, and the steps are as follows:

[0076] (1) Preparation of dispersed phase and continuous phase fluid

[0077] Preparation of dispersed phase fluid: Prepare three different concentrations of dispersed phase fluid, add three parts of terephthalaldehyde to three parts of soybean oil at room temperature, stir well until terephthalaldehyde dissolves in soybean oil to obtain three concentrations Different dispersed phase fluids, the concentrations of terephthalaldehyde in the three dispersed phase fluids are 0.0005g / mL, 0.00075g / mL and 0.0015g / mL respectively;

[0078] Preparation of continuous phase fluid: at room temperature, water-soluble chitosan with a deacetylation degree of 85%, a weight average molecular weight Mw≤5000g / mol, and hydroxyethyl cellulose with a weight average molecular weight Mw=500000g / mol were added to deionized water , fully stirred until dissolved, then adjust the p...

Embodiment 3

[0089] In the present embodiment, the ultrathin-walled chitosan microcapsules are prepared, and the steps are as follows:

[0090] (1) Preparation of dispersed phase and continuous phase fluid

[0091] Prepare the dispersed phase fluid: add terephthalaldehyde into the soybean oil at room temperature, stir well until the terephthalaldehyde dissolves in the soybean oil to obtain the dispersed phase fluid, the concentration of terephthalaldehyde in the dispersed phase fluid is 0.0075g / mL;

[0092] Prepare continuous phase fluid: prepare three kinds of continuous phase fluids with different water-soluble chitosan concentrations, three parts of water-soluble chitosan with deacetylation degree of 85%, weight average molecular weight Mw≤5000g / mol at room temperature, and three parts Add three parts of hydroxyethyl cellulose with weight average molecular weight Mw=500000 g / mol to three parts of deionized water, fully stir until dissolved, then adjust the pH value to 6.4 with 1mol / L ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
diameteraaaaaaaaaa
thicknessaaaaaaaaaa
thicknessaaaaaaaaaa
Login to View More

Abstract

The invention provides an ultrathin-wall chitosan microcapsule which is formed by carrying out a cross-linking reaction on chitosan and terephthalaldehyde and has the wall thickness of not higher than10nm. The preparation method of the ultrathin-wall chitosan microcapsule comprises the following steps: (1) preparing a dispersed-phase fluid and a continuous-phase fluid; (2) respectively filling different liquid inlets of a microfluid device with the dispersed-phase fluid and the continuous-phase fluid to form a monodispersed oil-in-water emulsion in the microfluid device, introducing the oil-in-water emulsion to a collecting vessel by an output pipe connected with the microfluid device, and carrying out crosslinking for 2-12h to form the ultrathin-wall chitosan microcapsule; and (3) washing the ultrathin-wall chitosan microcapsule by using water to remove a continuous phase on the outer wall of the microcapsule, and drying the washed ultrathin-wall chitosan microcapsule or dispersing the washed ultrathin-wall chitosan microcapsule into water so as to be stored. By using the ultrathin-wall chitosan microcapsule, the capsule wall thickness can be effectively reduced while the stability of the chitosan microcapsule is guaranteed.

Description

technical field [0001] The invention belongs to the field of chitosan microcapsule preparation, and relates to an ultrathin-wall chitosan microcapsule and a preparation method thereof. Background technique [0002] Microcapsules have the characteristics of small volume, large specific surface area and large internal cavity. Microcapsules can isolate the embedded active substance from the external environment to avoid degradation and inactivation of the substance; it can cover the bad smell of the substance, and can effectively control the release of the active substance and improve its utilization. Therefore, microcapsules have a wide range of applications in the fields of active substance delivery carriers, microreactors and the like. The use of microcapsules is determined to some extent by their structure and constituent materials. Compared with traditional microcapsules, microcapsules with ultra-thin-walled shells whose wall thickness does not exceed 100nm tend to have ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/14
CPCB01J13/14
Inventor 穆晓婷巨晓洁张璐褚良银谢锐汪伟刘壮
Owner 四川迈可隆生物科技有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com