Oxygen-carrying mitochondrial targeting photodynamic therapy nano platform, preparation method and application

Abstract

The invention belongs to the technical field of photodynamic therapy, and discloses a self-oxygen-carrying mitochondrial targeting photodynamic therapy nano platform, a preparation method and application. The preparation method comprises the following steps: regulating and controlling a growth structure through a two-step silicon source adding method to obtain eccentric organic silicon oxide, obtaining eccentric mesopore organic silicon oxide through a hydrothermal etching method, functionally modifying mitochondrial targeting components and a photosensitizer on the surface of the eccentric mesopore organic silicon oxide, and loading low-boiling-point oxygen-carrying perfluorocarbon in a cavity. The prepared photodynamic therapy nano-platform has a large internal cavity and mesoporous channels, can efficiently load oxygen-carrying perfluorinated carbon molecules to target mitochondria, and has high singlet oxygen generation characteristic and cancer cell killing characteristic after being irradiated by laser with specific wavelength. The preparation method is simple and easy to obtain, and the obtained product is high in yield and has huge application potential in the fields of tumor photodynamic therapy and the like.

Description

technical field [0001] The invention belongs to the technical field of photodynamic therapy, and specifically relates to a photodynamic nano-platform with self-carrying oxygen properties and mitochondrial targeting properties, a preparation method and application thereof. Background technique [0002] Photodynamic therapy is the use of photosensitizers to convert oxygen into cytotoxic reactive oxygen species under the irradiation of laser light with a suitable wavelength, thereby killing tumor cells. Compared with traditional tumor treatment methods, photodynamic therapy has the advantages of less trauma, good reproducibility, high spatial selectivity, and fewer side effects. As one of the three major elements of photodynamic therapy, oxygen is closely related to the therapeutic effect. Hypoxia prevalent in solid tumors and oxygen consumption during photodynamic therapy often form a vicious cycle, which is not conducive to adequate treatment of tumors. Effectively increasi...

AI Technical Summary

Problems solved by technology

However, due to the single role of organosilica nanoparticles as a nano-drug carrier, it is difficult to achieve the effect of treating tumors. Combining the characteristics of loading functional molecules with oxygen-carrying properties, mitochondrial targeting and photodynamic therapy, the mesoporous organic oxidation Silicon nanomaterials are more widely studied in biomedical applications, but more new applications remain to be explored

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