New application of graphdiyne nano-material serving as free radical scavenger and radiation protective agent

A technology of radioprotectants and nanomaterials, which is applied in the directions of non-active ingredients, such as medical preparations, antidote, drug combinations, etc., to achieve the effect of reducing damage

Active Publication Date: 2018-07-20
INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its use as a free radical scavenger and radioprotectant has not been reported

Method used

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  • New application of graphdiyne nano-material serving as free radical scavenger and radiation protective agent
  • New application of graphdiyne nano-material serving as free radical scavenger and radiation protective agent
  • New application of graphdiyne nano-material serving as free radical scavenger and radiation protective agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The preparation method of the graphdiyne nanomaterial modified by bovine serum albumin comprises the following steps:

[0042] (1) the graphdiyne powder is placed in an agate mortar and ground for 10 min;

[0043] (2) the graphdiyne after grinding is dispersed in ultrapure water to form the aqueous solution of graphyne, and the aqueous solution concentration of graphyne is 1mg / mL;

[0044] (3) the graphdiyne aqueous solution is carried out ice-bath ultrasonic crushing in the ultrasonic crusher, the ultrasonic crushing time is 12h, and the crushing power is 400W, obtains the aqueous solution of the graphdiyne nanomaterial;

[0045] (4) the graphyne nanomaterial is dispersed in ultrapure water to obtain an aqueous solution of the graphyne nanomaterial, and the aqueous solution concentration of the graphyne nanomaterial is 1 mg / mL;

[0046] (5) dissolving bovine serum albumin in ultrapure water to obtain an aqueous solution of bovine serum albumin, the concentration of th...

Embodiment 2

[0049] The difference from Example 1 is that the stirring time is 10h.

Embodiment 3

[0051] The difference from Example 1 is that the stirring time is 14h.

[0052] A preferred embodiment of the present invention will be described in detail below in conjunction with specific process parameters.

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Abstract

The invention discloses new application of a graphdiyne nano-material serving as a free radical scavenger and a radiation protective agent, and belongs to the technical fields of nano-materials, freeradical scavenging and radiation protection. The graphdiyne nano-material provided by the invention has a large conjugated pi bond structure, and also has a diyne bond structure with high reaction activity; because of the unique structures, the graphdiyne nano-material has good electron absorption capacity, so that free radicals can be effectively scavenged and can serve as the free radical scavenger. The graphdiyne has good free radical scavenging activity, can powerfully scavenge a large amount of ROS (Reactive Oxygen Species) produced by a body because of the induction of high-energy ray ina radiotherapy process, and the damage to normal tissues by the ROS is reduced, so that a radiation protecting effect is achieved. According to the new application of the graphdiyne nano-material serving as the free radical scavenger and the radiation protective agent, the graphdiyne nano-material is applied to free radical scavenging for the first time, and a new opportunity is provided for developing a new free radical scavenger for oxidation resistance.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, free radical scavenging and radiation protection, and relates to a new application of a graphyne nanomaterial as a free radical scavenger and a radiation protection agent, in particular to a graphyne nanometer modified based on bovine serum albumin. New uses of materials as free radical scavengers and radioprotectants. Background technique [0002] Reactive oxygen species (ROS) free radicals play an important role in the oxidative damage of the body. They can interact with macromolecules in cells (such as DNA, RNA, proteins, and cell membranes) and cause cellular damage, thereby damaging the body. Especially in the process of radiotherapy, the high-energy rays used will radiate the water in the cells to generate a large amount of ROS, causing radiation damage to the body. Therefore, the development of effective free radical scavengers is of great significance for the fields of anti-oxidat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/44A61K47/64A61P39/06A61P39/00
CPCA61K33/44
Inventor 谷战军谢佳妮董兴华赵宇亮
Owner INST OF HIGH ENERGY PHYSICS CHINESE ACAD OF SCI
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