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A kind of bone filling material and preparation method thereof

A technology of filling materials and biomaterials, applied in the field of bone filling materials, can solve the problems of non-absorbability and achieve the effect of wide application, effective filling and gluing of broken bones, and simple manufacturing process

Active Publication Date: 2021-09-28
苏州奥森佩克医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The prior art bone cement polymethylmethacrylate (Polymethylmethacrylate, PMMA) is a bone filling and cementing material commonly used in clinical orthopedics. It has high-strength physical properties. It is an ester chemical composition and does not combine with water molecules to form hydrogen bonds. , therefore, can dry-bond fractures in bones in an aqueous environment, but has the disadvantage of permanent non-absorbable

Method used

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  • A kind of bone filling material and preparation method thereof
  • A kind of bone filling material and preparation method thereof
  • A kind of bone filling material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Measure a certain volume of glyceryl monostearate powder, put it into a container, heat and melt, and use glyceryl monostearate:calcium phosphate as a volume ratio of 1:1, just mix it evenly, and it can be prepared on-site during the operation. It can also be prepared in advance, and can be injected after heating and melting during application.

[0069] For the test results of this experimental module, see figure 1 (Module 1 with a pressure displacement of 2 mm is the test sample).

[0070] Table 1 Biomechanical test results of calcium phosphate group

[0071] no Maximum force (N) Maximum deformation (mm) 1 2.844 4 2 2.740 4 3 1.672 4 4 2.729 4 5 2.171 4 average value 2.431 4

Embodiment 2

[0073] Measure a certain volume of glyceryl monostearate powder, put it into a container, heat and melt, and use glyceryl monostearate:calcium sulfate as a volume ratio of 1:1, just mix it evenly, and it can be prepared on-site during the operation. It can also be prepared in advance, and can be injected after heating and melting during application.

[0074] For the test results of this experimental module, see figure 2 .

[0075] Table 2 Biomechanical test results of calcium sulfate group

[0076] no Maximum force (N) Maximum deformation (mm) 1 17.693 5.00 2 18.021 5.00 3 19.667 5.00 4 14.587 5.00 average value 17.492 5

Embodiment 3

[0078] Measure the glyceryl monostearate powder of a certain volume, put it into a container, heat and melt, and use glyceryl monostearate: hydroxyapatite as a volume ratio of 1:1, (mixed material group calcium phosphate, calcium sulfate The volume of hydroxyapatite and hydroxyapatite is also 1:1:1, that is, the volume is 1 / 3), and they can be mixed evenly. It can be prepared on-site during the operation, or it can be prepared in advance. It can be injected after heating and melting during application. .

[0079] For the test results of this experimental module, see image 3 .

[0080] Table 3 Biomechanical test results of hydroxyapatite group

[0081] no Maximum force (N) Maximum deformation (mm) 1 9.632 4.00 2 8.012 5.00 3 8.262 5.00 4 8.5 5.00 average value 8.608 4.75

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Abstract

The present invention claims to protect a bone filling material and its preparation method. The method utilizes glycerol monostearate as a matrix, utilizes the thermal melting property of glyceryl monostearate, and heats and melts , add clinically required bone material, dissolve it and modulate it into a fluid state, and achieve the purpose of fluid perfusion in a minimally invasive way; the bone biomaterial is selected from clinically available calcium phosphate (or calcium phosphate derivatives), calcium sulfate, hydroxyl Apatite, bone powder, or a mixture of several of them, and (or) bone growth-promoting drugs or targeted therapeutic drugs. The present invention utilizes the self-property of glyceryl monostearate to prepare, injects into the body and dries immediately, and is safe and absorbable in the body. The invention realizes the application of the minimally invasive fluid perfusion approach of the clinically absorbable bone filling material, and is also used for the modification of the commonly used clinical bone filling material to achieve the purpose of fluid and flexible filling.

Description

technical field [0001] The invention belongs to the technical field of medical materials, in particular to a bone filling material implanted in the body. Background technique [0002] Bone defect has always been a problem in the orthopedic field! Especially in the field of minimally invasive application technology, there are many difficulties. [0003] In the process of fracture healing, the callus formation period is important within 3 months after fracture. Especially the formation period of the original callus within 1 month after the fracture. Therefore, how to effectively reduce and fix the fracture during this period, and effectively fill the bone defect, without affecting the natural bone healing process of the fracture, is the core point of all fracture clinical treatments. [0004] Under the clinical trend of minimally invasive treatment, the way of implanting bone materials has become the bottleneck of clinical technology application. How to effectively and saf...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/02A61L27/36A61L27/58
CPCA61L27/025A61L27/12A61L27/3608A61L27/58A61L2400/06A61L2430/02
Inventor 刘小勇杨惠林罗宗平唐天驷
Owner 苏州奥森佩克医疗科技有限公司