Stable fat-soluble active component composition, and microcapsule, preparation method and applications thereof

An active ingredient and fat-soluble technology, which is applied in the field of new green antioxidant compositions, can solve the problems that the dosage and antioxidant ratio are not clearly described, and the combined use of antioxidants is not mentioned, so as to achieve the effect of improving stability

Pending Publication Date: 2018-07-27
ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The antioxidants mentioned in the above patent documents, including tocopherol and vitamin C palmitate, do not mention the combined ...

Method used

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  • Stable fat-soluble active component composition, and microcapsule, preparation method and applications thereof
  • Stable fat-soluble active component composition, and microcapsule, preparation method and applications thereof
  • Stable fat-soluble active component composition, and microcapsule, preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Under nitrogen protection, vitamin A crystallization, vitamin C palmitate and α-tocopherol were melted at 75°C to prepare vitamin A melt oil. The weights of vitamin A, vitamin C palmitate, and α-tocopherol were determined according to the factor level setting table in Table 1 and the orthogonal experiment arrangement table in Table 2. The vitamin A melted oil was put in a sampling bottle, sealed and protected from light, stored at 40°C, and its content was detected after 0, 2, 4, and 6 days respectively.

[0039] Table 1 Factor level setting table

[0040]

[0041] Remarks: The percentage values ​​in the table are the ratio of antioxidants to vitamin A

[0042] Table 2 Arrangement of Orthogonal Experiments

[0043]

[0044] The results of 2 days, 4 days, and 6 days were analyzed respectively, and the comprehensive judgment was used as the final experimental result to conduct a range analysis on the content retention rate, and select the primary and secondary rel...

Embodiment 2

[0049] Under the protection of nitrogen, melt the mixture of vitamin A palmitate, vitamin C palmitate and β-tocopherol at 65°C to prepare vitamin A palmitate melt oil. Dissolve gelatin and glucose in water at 65°C to form an aqueous solution of gelatin and glucose. Under high-speed shearing conditions, the vitamin A palmitate melted oil is poured into the above-mentioned aqueous phase solution for emulsification, degassing, and homogenization to obtain a stable emulsion. The vitamin A palmitate emulsion was placed in a sampling bottle, sealed and protected from light, stored at 40°C, and its content was detected after 0, 1, 2, and 3 weeks, respectively. The retention rate data of emulsion content in different antioxidant ratios are shown in Table 4 below.

[0050] Table 4. Statistical table of content retention rate of different antioxidant combinations in vitamin A palmitate emulsion

[0051]

[0052] It is evident from the data in Table 4 that within the range of the fo...

Embodiment 3

[0054] Under the protection of nitrogen, 50 kg of vitamin A acetate crystallization, 0.5 kg of vitamin C palmitate and 3.5 kg of synthetic mixed tocopherols were melted at 85°C to prepare vitamin A acetate melt oil. 75 kilograms of gelatin and 50 kilograms of glucose are dissolved in 130 kilograms of 60 ℃ of water, are made into 49% gelatin glucose aqueous phase solution.

[0055] Under high-speed shearing conditions, pour vitamin A acetate melted oil into the above water phase solution for emulsification, degassing, and homogenization to obtain a stable emulsion, which is sent to the starch bed for spray granulation, then fluidized drying, high temperature After cross-linking, 218 kg of water-repellent vitamin A acetate microcapsules were obtained. Through HPLC analysis, the vitamin A acetate content is 520,000 IU / g, and the microencapsulation yield is 95%. The vitamin A ester microcapsules were placed in a sampling bottle to be sealed and protected from light. After being s...

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Abstract

The invention provides a stable fat-soluble active component composition, and a microcapsule, a preparation method and applications thereof, wherein the fat-soluble active component composition comprises tocopherol, vitamin C palmitate and a fat-soluble active component, a weight ratio of the tocopherol to the vitamin C palmitate is 2-8:1, and a weight ratio of the combination of the tocopherol and the vitamin C palmitate to the fat-soluble active component is 7-13:100. According to the present invention, the novel antioxidant combination with no contraindication is obtained by screening the combination of the antioxidant and adjusting the ratio and the dose so as to improve the stability of the fat-soluble active component.

Description

technical field [0001] The invention relates to a novel green antioxidant composition capable of increasing vitamin A esters, in particular to a stable fat-soluble active ingredient composition, microcapsules and a preparation method and application thereof. Background technique [0002] Vitamins are necessary for animal nutrition and production, and play an extremely important role in the body's metabolism, growth, development, and health. Vitamin A is a very important member of the vitamin A ester family. It has very important functions in visual health, bone health, reproduction and cell division and reproduction. It is unimaginable to lack vitamin A in the human body. [0003] Vitamin A is a light yellow crystalline solid, insoluble in water, soluble in fat and various fat solvents, easily deteriorated when exposed to light, heat, and oxygen, and easily destroyed. Therefore, when making vitamin A additives, it must first be esterified , generally made into microcapsule ...

Claims

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Application Information

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IPC IPC(8): A61K9/50A61K47/22A61K31/22A61K31/122A61P3/02A61K8/67A61Q19/00A23L33/10A23L33/155A23L33/15A23P10/20A23L2/38A23K20/174A23K20/121
CPCA61Q19/00A23K20/121A23K20/174A23L2/38A23L33/10A23L33/15A23L33/155A23P10/20A61K8/671A61K8/676A61K8/678A61K9/5015A61K31/122A61K31/22A23V2002/00A61K2800/10A23V2200/30A23V2250/702A23V2250/712A23V2250/5432A23V2250/61A61K31/355A61K31/375A61K31/07A61K31/59A61K31/015A61K31/20A61K9/5089A61P39/06B01J13/043A61K8/11A23P10/30A61K2300/00A61K2800/522A23V2250/708
Inventor 毛国泉朱宏铭马文鑫梁智平钱力范鲁比胡四平李春温善萍王琴兰孔华娟
Owner ZHEJIANG MEDICINE CO LTD XINCHANG PHAMACEUTICAL FACTORY
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