Surface-enhanced Raman substrate microspheres with micron size and preparation method thereof

A surface-enhanced Raman and surface-enhanced technology, which is applied in the field of composite materials, can solve the problems that cannot be distinguished and positioned one by one, cannot be moved to the designated position, and the individual cannot be operated, so as to reduce low reproducibility and inaccurate The effects of stability, uniform size, and good application prospects

Inactive Publication Date: 2018-08-03
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, dielectric microspheres / nanoparticles have become a research hotspot for SERS-enhanced substrates due to their high stability, simple operation, and high SERS activity. Lack of precise control over aspects such as temperature and "hot spot" locations hinders their practical application
[0003] Although many novel structures of nano-substrates with high Raman-enhancing activity have been developed, they cannot be distinguished and localized individually under conventional light microscopy, and the individuals cannot be manipulated, nor can they be moved from one site to another. specified site, thus limiting many applications to

Method used

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  • Surface-enhanced Raman substrate microspheres with micron size and preparation method thereof
  • Surface-enhanced Raman substrate microspheres with micron size and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0016] (1) Mix 5.0 g GMA, 1.0 g PVP, 87 mL ethanol, 13 mL ionized water, 0.1 g AIBN and fluorescent probe molecules, react at 70 °C for 12 h, centrifuge to separate the product, and then dry it in vacuum at 50 °C for 2 h obtains PGMA microspheres;

[0017] (2) Add 10 mg of PGMA microspheres obtained in step (1) to 50 mL of 5 mg AgNO 3 Add 0.05 g of cuprous oxide to the ethanol solution, then place it in a shaker, shake it at 50°C for 60 min, wash it with ethanol for 2-3 times after centrifugation, and dry it in vacuum at 50°C for 2 h to obtain PGMA / Ag- NPs substrate microspheres.

Embodiment 2

[0019] (1) Mix 5.0 g GMA, 1.0 g PVP, 87 mL ethanol, 13 mL ionized water, 0.1 g AIBN, and fluorescent probe molecules, react at 70 °C for 12 h, centrifuge to separate the product, and then dry it in vacuum at 50 °C for 2 h obtains PGMA microspheres;

[0020] (2) Add 10 mg of PGMA microspheres obtained in step (1) to 50 mL of 20 mg AgNO 3 Add 0.1 g of cuprous chloride to the ethanol solution, then place it in a shaker, shake it at 50°C for 60 min, wash it with ethanol for 2-3 times after centrifugation, and dry it in vacuum at 50°C for 2 h to obtain PGMA / Ag -NPs substrate microspheres;

Embodiment 3

[0022] (1) Mix 5.0 g GMA, 1.0 g PVP, 87 mL ethanol, 13 mL ionized water, 0.1 g AIBN, and fluorescent probe molecules, react at 70 °C for 12 h, centrifuge to separate the product, and then dry it in vacuum at 50 °C for 2 h obtains PGMA microspheres;

[0023] (2) Add 10 mg of PGMA microspheres obtained in step (1) to 50 mL of 50 mg AgNO 3 Add 0.4 g of n-butylamine to the ethanol solution, then place it in a shaker, shake it at 50°C for 60 min, wash it with ethanol for 2-3 times after centrifugation, and dry it in vacuum at 50°C for 2 h to obtain PGMA / Ag- NPs substrate microspheres;

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Abstract

The invention discloses surface-enhanced Raman substrate microspheres with a micron size and a preparation method thereof, which belong to the technical field of a composite material. According to theinvention, PGMA is taken as a microspheres base material, a precipitation polymerization method and an in-situ reduction deposition technology are employed, sodium borohydride, cuprous oxide, cuprouschloride or n-butylamine are taken as reducing agents, Ag-NPs is deposited at the surface of PGMA microspheres, and the PGMA / Ag-NPs surface-enhanced Raman substrate microspheres can be formed. The substrate microspheres have strong surface-enhanced Raman activity for Raman label molecules such as p-aminothiophenol (ABT), p-chlorothiophenol (CBT), and thiohydroquinone (HBT), and have good application prospect on the chemical, food and biological detection aspects.

Description

technical field [0001] The invention belongs to the technical field of composite materials, and in particular relates to a micron-sized surface-enhanced Raman substrate microsphere and a preparation method thereof. Background technique [0002] Surface-enhanced Raman spectroscopy (SERS) has high sensitivity, good selectivity, and rapid analysis; it does not destroy the structure of the sample during detection, can provide non-destructive detection, and can provide single-molecule level detection. Therefore, it has attracted extensive attention in chemical analysis, environmental detection, biological diagnosis and so on. At present, dielectric microspheres / nanoparticles have become a research hotspot for SERS-enhanced substrates due to their high stability, simple operation, and high SERS activity. The lack of precise control over aspects such as temperature and "hot spot" locations hinders their practical application. [0003] Although many novel structures of nano-substr...

Claims

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Application Information

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IPC IPC(8): B01J13/02G01N21/65
CPCB01J13/02G01N21/658
Inventor 游力军宋立岛黄慈许珂张其清
Owner FUZHOU UNIVERSITY
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