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Preparation method of titanium base biomedical gradient composite material

A composite material and biomedical technology, which is applied in the field of preparation of titanium-based biomedical gradient composite materials, can solve the problems of cytotoxic reaction nerve and physiological disorder, stress-shielding, implant loosening, etc., and achieves short sintering time and good quality. Interfacial bonding, the effect of lowering the elastic modulus

Active Publication Date: 2018-08-10
KUNMING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, since the elastic modulus (110GPa) of these two materials is much higher than that of human natural bone (2-30GPa), it is easy to produce a "stress-shielding" phenomenon, resulting in loosening or loosening of the implant, thus Finally, it leads to implant failure; in addition, because TC4 alloy contains elements such as Al and V that are harmful to the human body, it will inevitably cause cytotoxic reactions and neurological and physiological disorders in the human body in clinical applications.

Method used

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  • Preparation method of titanium base biomedical gradient composite material
  • Preparation method of titanium base biomedical gradient composite material
  • Preparation method of titanium base biomedical gradient composite material

Examples

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Embodiment 1

[0022] A preparation method of a titanium-based biomedical graded composite material, specifically comprising the following steps:

[0023] (1) Weigh the Ti, Nb and Zr powders with a particle size of 75 μm according to the mass percentage of Nb: 15%, Zr: 15%, Ti: 70%, and use a ball-to-material ratio of 5:1 and 200r / min Mix the powder by speed ball milling for 5 hours to obtain figure 1 The TiNbZr mixed powder shown.

[0024] (2) Ti powder with a particle size of 150 μm and NH with a particle size of 500 μm 4 HCO 3 The powder is mixed to obtain Ti-NH 4 HCO 3 Mixed powder, in mixed powder Ti-NH 4 HCO 3 The mass percentage of Ti powder in the medium is 70%, NH 4 HCO 3 The mass percentage of powder is 30%.

[0025] (3) Ti-NH to be obtained 4 HCO 3 The mixed powder and TiNbZr alloy mixed powder are respectively filled into the outer layer and inner layer of the sleeve with the annular partition, and after the partition is taken out, the pressure testing machine is used ...

Embodiment 2

[0032] A preparation method of a titanium-based biomedical graded composite material, specifically comprising the following steps:

[0033] (1) Weigh the Ti, Nb and Zr powders with a particle size of 23 μm according to the mass percentage of Nb: 10%, Zr: 20%, Ti: 70%, and use the ball-to-material ratio of 3:1 and 400r / min Speed ​​ball milling mixed powder for 2 hours to obtain TiNbZr mixed powder.

[0034](2) Ti powder with a particle size of 23 μm and NH with a particle size of 300 μm 4 HCO 3 The powder is mixed to obtain Ti-NH 4 HCO 3 Mixed powder, in mixed powder Ti-NH 4 HCO 3 Middle NH 4 HCO 3 The mass percent of powder is 5wt.%, 15wt.% and 30wt.%.

[0035] (3) Then the obtained TiNbZr mixed powder and Ti-NH 4 HCO 3 The mixed powder is filled into the inner and outer layers of the mold sleeve, and pressed on a pressure testing machine with a pressure of 50 MPa; finally, the pressed green body is put into a graphite mold, and sintered on a spark plasma sintering e...

Embodiment 3

[0039] A preparation method of a titanium-based biomedical graded composite material, specifically comprising the following steps:

[0040] (1) Weigh the Ti, Nb, Zr powders with purity of 99.5%, 99.95% and 99.95% respectively, and particle size of 70 μm, according to mass percentage (wt%) 70%: 20%: 10% ratio; then put into ball mill Ball milling was carried out at 600r / min in the tank. During the ball milling process, the ball milling medium is stainless steel balls with a ball-to-material ratio of 1:1, sealed with alcohol and then vacuumed to 20Pa, then ball milled for 10 hours, and the obtained metal mixed powder is dried.

[0041] (2) Ti powder with a particle size of 70 μm and NH with a particle size of 100 μm 4 HCO 3 The powder is mixed to obtain Ti-NH 4 HCO 3 Mixed powder, in mixed powder Ti-NH 4 HCO 3 The mass percentage of Ti powder in the medium is 80%, NH 4 HCO 3 The mass percent of the powder is 20%; the obtained Ti-NH 4 HCO 3 The mixed powder and TiNbZr a...

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Abstract

The invention discloses a preparation method of a titanium base biomedical gradient composite material, and belongs to the technical field of biomedical material preparation. The method comprises thefollowing main process steps: Ti-NH4HCO3 mixed powder and TiNbZr alloy mixed powder are respectively filled in an outer layer and an inner layer of a sleeve with an annular separation plate, and are molded by pressing after taking out of the separation plate to obtain a cylinder blank with different materials of a core part and an outer layer after removal of the sleeve; after the cylinder blank is sintered by SPS, a pore forming agent is volatilized; and a block is taken out from a mold after cooling to obtain a TiNbZr / porous Ti gradient composite material with two layers of classification structures (a core part is compact TiNbZr alloys and the surface is porous titanium). The composite material prepared by the method has excellent biocompatibility and low elastic modulus matched with skeletons, is excellent in compressive resistance, can serve as an artificial bone tissue repair or replacement material, and has the characteristics of short preparation flow and simple and environment-friendly process.

Description

technical field [0001] The invention relates to a preparation method of a titanium-based biomedical gradient composite material, which belongs to the technical field of preparation of biomedical materials. Background technique [0002] Among the artificial biomedical metal materials currently used in clinical practice, pure titanium (CP-Ti) and TC4 (Ti-6Al-4V) alloys are the preferred hard tissue replacement and repair materials for artificial, spinal orthopedic internal fixation systems, and dental implants. . However, since the elastic modulus (110GPa) of these two materials is much higher than that of human natural bone (2-30GPa), it is easy to produce a "stress-shielding" phenomenon, resulting in loosening or loosening of the implant, thus Finally, it leads to implant failure; in addition, because TC4 alloy contains elements such as Al and V which are harmful to the human body, it will inevitably cause cytotoxic reactions and neurological and physiological disorders in ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F7/02B22F3/11
CPCB22F3/1125B22F7/006
Inventor 张玉勤郭谦何远怀蒋业华周荣
Owner KUNMING UNIV OF SCI & TECH
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