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Blood clotting time detecting method and device

A technology of coagulation time and detection method, applied in the biological field, can solve problems such as inaccurate detection results, and achieve the effect of improving detection accuracy

Inactive Publication Date: 2018-08-17
SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of this, the embodiment of the present invention provides a blood coagulation time detection method and device to solve the problem of inaccurate detection results in the existing household blood coagulation detection methods

Method used

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  • Blood clotting time detecting method and device
  • Blood clotting time detecting method and device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] figure 1 Shows a flow chart of an optional blood coagulation time detection method according to an embodiment of the present invention, as figure 1 As shown, the method includes:

[0031] In step S11, the response signal of the piezoelectric film sensor to the preset excitation signal is obtained, and the surface of the piezoelectric film sensor is provided with a blood sample to be tested and a blood coagulation reagent.

[0032] The core of the blood coagulation detection method based on the piezoelectric principle is a piezoelectric film sensor. Specifically, the piezoelectric film sensor can be a quartz crystal microbalance sensor (QCM), a surface acoustic wave sensor (SAW), a thin film resonant Lamb wave sensor (LAMB ), film bulk acoustic wave sensor (FBAR) and so on.

[0033] The blood sample to be tested and the coagulation reagent are arranged on the surface of the piezoelectric film sensor, which can be mixed with the blood sample to be tested and the coagula...

Embodiment 2

[0082] Figure 9 A schematic diagram showing an optional coagulation time detection device according to an embodiment of the present invention, as shown in Figure 9 As shown, the device includes:

[0083] The obtaining module 41 is used to obtain the response signal of the piezoelectric film sensor to the preset excitation signal, the surface of the piezoelectric film sensor is provided with the blood sample to be tested and the blood coagulation reagent; for details, refer to the detailed description of step S11 in the first embodiment.

[0084] The determination module 42 is configured to determine the variation relationship of the dissipation factor of the piezoelectric film sensor with time according to the response signal; for details, refer to the detailed description of step S12 in the first embodiment.

[0085] The processing module 43 is configured to determine the coagulation time of the blood sample to be tested according to the variation relationship. For detail...

Embodiment approach

[0090] As an optional implementation manner of the present invention, the acquiring unit may include:

[0091] Acquisition subunit, used to obtain the envelope of the response signal within a single test cycle.

[0092] The calculation subunit is used to determine the time constant of the piezoelectric film sensor in the current test cycle according to the envelope.

[0093] A subunit is generated for determining the dissipation factor of the piezoelectric film sensor in the current test cycle according to the time constant and the resonance frequency of the piezoelectric film sensor.

[0094] For details, refer to the detailed description of step S22 in the first embodiment.

[0095] As an optional implementation of the present invention, the frequency of the preset excitation signal changes within a predetermined frequency range, and the determining module may include:

[0096] The second acquiring unit is used to respectively acquire the quality factor of the piezoelectri...

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Abstract

The invention discloses a blood clotting time detecting method and device. The blood clotting time detecting method comprises the following steps: obtaining a response signal of a piezoelectric film sensor for a preset excitation signal, wherein the surface of the piezoelectric film sensor is provided with a blood sample to be tested and a blood coagulation reagent; and determining the change relationship of the dissipation factor of the piezoelectric film sensor along with time according to the response signal; and determining the blood clotting time of the blood sample to be tested accordingto the change relationship of the dissipation factor with the time. The blood clotting time detecting method solves the problem of inaccurate detection results in the existing domestic blood clottingdetection method.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method and device for detecting coagulation time. Background technique [0002] The four blood coagulation tests are one of the medical examination items and must be checked for preoperative patients, thrombosis patients and anticoagulant drug users. The four blood coagulation tests include prothrombin time (PT) and activated partial thromboplastin time (APTT). , thrombin time (TT) and fibrinogen (FIB). Especially for postoperative patients, patients with thrombosis, or people who need to closely monitor coagulation function, coagulation function indicators need to be tested frequently, and a coagulation detection method suitable for home use is needed. [0003] The existing detection method suitable for home use is a blood coagulation detection method based on the piezoelectric principle, and its core is a piezoelectric film sensor. In blood coagulation detection, the coagulatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/00G01N33/86
CPCG01N27/00G01N33/86
Inventor 周连群姚佳丰斌郭振李传宇张威张芷齐
Owner SUZHOU INST OF BIOMEDICAL ENG & TECH CHINESE ACADEMY OF SCI