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Mineralized collagen-based moderate-strength artificial bone repair material and preparation method thereof

A technology of mineralized collagen and repair materials, applied in the field of bone materials, can solve the problems of inapplicability, low strength, and limited scope of use

Active Publication Date: 2018-08-21
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is similar to natural bone in terms of microstructure and composition, and has good biocompatibility and osteoinductive repair ability. It is an excellent bone repair material. The disadvantage is that the strength of mineralized collagen repair materials is low. (Generally 1 ~ 2Mpa), which limits the scope of use
However, the applicant found that this method simply composites polymer materials and mineralized collagen into a bone repair material. Although the bone repair material also has a certain strength, the strength is generally relatively low, and it is also not applicable to the tibial plateau, Evans heel section, etc. Bone surgery, Cotton wedge opening osteotomy

Method used

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  • Mineralized collagen-based moderate-strength artificial bone repair material and preparation method thereof
  • Mineralized collagen-based moderate-strength artificial bone repair material and preparation method thereof
  • Mineralized collagen-based moderate-strength artificial bone repair material and preparation method thereof

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preparation example Construction

[0058] The invention provides a preparation method of a mineralized collagen-based medium-strength artificial bone repair material, the preparation method comprising:

[0059] (1) Preparation of polymer / mineralized collagen composites

[0060] The high molecular polymer is dissolved in an organic solvent, and the concentration is prepared to be 0.05-0.15g / mL (for example, it can be specifically 0.05g / mL, 0.08g / mL, 0.10g / mL, 0.12g / mL or 0.15g / mL mL) of the first high polymer solution and a concentration of 0.08 to 0.20 g / mL (for example, can be specifically 0.08 g / mL, 0.10 g / mL, 0.15 g / mL or 0.20 g / mL) of the second high polymer solution. The polymer used can be selected from polyε-caprolactone with a viscosity of 1.0 to 3.0dl / g, polylactic acid with a molecular weight of 100,000 to 300,000, and polylactic acid-glycolic acid copolymers with a molecular weight of 100,000 to 300,000. any of the things. The first high polymer solution and the second high polymer solution can be...

Embodiment 1

[0090] Such as figure 1 Shown, preparation method comprises the steps:

[0091] Step 1, the preparation of mineralized collagen dry powder specifically includes:

[0092] S1. Dissolving collagen in hydrochloric acid to prepare an acid solution of collagen, wherein the concentration of collagen is 0.5 mg / mL;

[0093] S2. Continue to stir the solution obtained in step S1, and slowly add the solution containing calcium ions dropwise. The amount of calcium ions added is 0.01 mol of calcium ions per gram of collagen;

[0094] S3, continue to stir the solution obtained in S2, slowly drop the solution containing phosphate ions, the molar ratio of the amount of phosphate ions added to the amount of calcium ions added in step S2 is Ca / P=1.5;

[0095] S4. Continue to stir the solution obtained in step S3, and slowly add NaOH solution dropwise until the pH of the mixed system is 6-8. When the pH=5-6, the mixed system begins to precipitate, and when the pH=7, the mixed system appears a ...

Embodiment 2

[0114] Preparation method is basically the same as Example 1, except that:

[0115] Use polylactic acid with a molecular weight of 100,000 to prepare the No. 1 polymer solution, and the mass volume concentration is 0.15g / mL;

[0116] Mineralized collagen dry powder and No. 1 high polymer solution are mixed according to the mass ratio of 1:1;

[0117] Use polylactic acid with a molecular weight of 300,000 to prepare a No. 2 polymer solution with a concentration of 0.20 g / mL;

[0118] The mixing ratio of No. 2 high polymer solution and hard polymer / mineralized collagen composite material particles is 4:3 by mass.

[0119] The shape of the final bone repair material is a wedge, such as image 3 shown.

[0120] It can be made into different models according to the needs, and the specific conditions of each model are shown in the table below.

[0121]

[0122] After testing, the bone repair material has a strength of 38MPa and a porosity of 45%.

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Abstract

The invention relates to a mineralized collagen-based moderate-strength artificial bone repair material and a preparation method thereof. The preparation method comprises the following steps: preparing a polymer / mineralized collagen composite material, preparing hard polymer / mineralized collagen composite material particles and preparing the mineralized collagen-based moderate-strength artificialbone repair material. By utilizing the method, the bone repair material with a certain supporting strength and a certain porosity can be obtained; the material can be used in parts requiring a certainbearing capacity, such as tibial platforms, Evans heel osteotomy, and Cotton wedge open osteotomy.

Description

technical field [0001] The invention relates to the technical field of bone materials, in particular to a mineralized collagen-based medium-strength artificial bone repair material and a preparation method thereof. Background technique [0002] Bone tissue is the largest organ in the human body and is also the most likely to cause defects. Every year, millions of patients with bone tissue defects need surgical treatment. The loss of bone organs or tissue defects caused by osteoporosis, trauma, tumor, and infection has become one of the problems that plague the healthy life of human beings. Clinically, bone graft repair and reconstruction surgery is usually performed to restore the shape and function of the defect site. Bone graft has become the graft with the largest demand after blood transfusion, and there is a trend of increasing year by year. [0003] At present, implant materials for the treatment of bone defects can be roughly divided into autologous bone, allogeneic ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/48A61L27/56A61L27/58
CPCA61L27/46A61L27/48A61L27/56A61L27/58A61L2430/02C08L89/00C08L67/04
Inventor 何志敏宋天喜崔福斋仇志烨崔云胡艳丽朱金亮崔菡
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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