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A kind of chitosan oligosaccharide diprimary amine cross-linked gel

A technology of cross-linked gel and chitosan oligosaccharide, which is applied in the field of chitosan oligosaccharide double-primary amine cross-linked gel, can solve the problems of difficult modification, limited application range, poor water solubility of chitosan, etc., and achieves a simple and convenient synthesis method. Raw materials are readily available and conditions are easy to control

Active Publication Date: 2021-01-29
CHANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the poor water solubility of chitosan, it is difficult to modify, and most of the obtained polymers are in powder form, which greatly limits its application range.

Method used

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  • A kind of chitosan oligosaccharide diprimary amine cross-linked gel
  • A kind of chitosan oligosaccharide diprimary amine cross-linked gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Weigh 5g chitosan oligosaccharide, add 40mL water, fully dissolve.

[0018] (2) Weigh 1.435 g of epichlorohydrin, add it into the chitosan oligosaccharide solution, stir at a constant temperature of 40° C. at a stirring speed of 150 rpm, and react for 24 hours.

[0019] (3) After the reaction, extract with 20 mL of ether, and take the water phase.

[0020] (4) Add 1.76 g tetraethylenepentamine to the solution, stir at a constant temperature of 50° C. at a stirring speed of 150 rpm, and react for 6 hours to obtain chitosan oligosaccharide tetraethylenepentamine cross-linked gel.

Embodiment 2

[0022] (1) Weigh 5g chitosan oligosaccharide, add 40mL water, fully dissolve.

[0023] (2) Weigh 1.435 g of epichlorohydrin, add it into the chitosan oligosaccharide solution, stir at a constant temperature of 80° C. at a stirring speed of 150 rpm, and react for 12 hours.

[0024] (3) After the reaction, extract with 20 mL of ether, and take the water phase.

[0025] (4) Add 1.76 g tetraethylenepentamine to the solution, stir at a constant temperature of 30° C. at a stirring speed of 150 rpm, and react for 12 hours to obtain chitosan oligosaccharide tetraethylenepentamine cross-linked gel.

Embodiment 3

[0027] (1) Weigh 5g chitosan oligosaccharide, add 40mL water, fully dissolve.

[0028] (2) Weigh 2.87g of epichlorohydrin, add it into the chitosan oligosaccharide solution, stir at a constant temperature of 80° C. at a stirring speed of 150 rpm, and react for 12 hours.

[0029] (3) After the reaction, extract with 20 mL of dichloromethane, and take the water phase.

[0030] (4) Add 3.52 g tetraethylenepentamine into the solution, stir at a constant temperature of 30° C. at a stirring speed of 150 rpm, and react for 12 hours to obtain chitosan oligosaccharide tetraethylenepentamine cross-linked gel.

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Abstract

The invention discloses a chitosan oligosaccharide bis-primary amine cross-linked gel. Water-soluble chitosan oligosaccharides are used as raw materials, which are cross-linked with bis-primary amines. The invention has simple process and mild reaction conditions. The obtained gel contains a large number of active groups, which is beneficial to its application in aspects such as adsorption and drug sustained release.

Description

technical field [0001] The invention belongs to the field of natural polymer modification, and in particular relates to a chitosan oligosaccharide bis-primary amine cross-linked gel. Background technique [0002] Since the French scholar H. Braconnot first extracted chitin from fungi in 1811, chitin and its derivatives have gradually become an important research object of scholars at home and abroad. After chitin is deacetylated, if more than 55% of the N-acetyl group is removed, chitosan is obtained. Now chitosan has been widely used in many fields such as medicine and health, environmental protection, food industry, light textile chemical industry and agriculture. With the continuous maturity of chitosan preparation methods, especially the use of enzymatic hydrolysis combined with physical degradation, its application prospects in the above-mentioned various fields are also broader. A series of low molecular weight chitosans, also known as chitooligosaccharides, can be o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/24C08J3/075C08L5/08
CPCC08J3/075C08J3/24C08J2305/08
Inventor 梅金凤张卉李忠玉
Owner CHANGZHOU UNIV