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Preparation method and application of modified short-straight-chain starch

A technology of short amylose and carboxymethyl short amylose, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, pharmaceutical formulations, etc. The problem of low starch charge and easy aggregation has achieved the effect of green and environmental protection in the preparation process, simple preparation method and improved stability

Inactive Publication Date: 2018-08-28
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation of starch nanoparticles from short amylose has good prospects for industrial application, but short amylose itself has less charge and is easy to aggregate in the aqueous phase, which limits the application of short amylose

Method used

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  • Preparation method and application of modified short-straight-chain starch
  • Preparation method and application of modified short-straight-chain starch
  • Preparation method and application of modified short-straight-chain starch

Examples

Experimental program
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Effect test

Embodiment 1

[0039] The influence of embodiment 1 ethanol solution volume concentration and starch milk concentration on the properties of short amylose

[0040] (1) Use ethanol solution to adjust the short amylose solution into starch milk with a concentration of 10%, and the volume concentration of the ethanol solution is as shown in Table 1;

[0041] (2) under stirring state, add 2g sodium hydroxide to described starch slurry, react, control reaction temperature to be 40 ℃, reaction time is 1h;

[0042] (3) Add 2g of chloroacetic acid to the reaction system treated in (2), the time of adding chloroacetic acid is controlled at 10min, and the reaction temperature is 40°C;

[0043] (4) After etherification, adjust the pH value to 7.0 with hydrochloric acid, wash with ethanol with a volume concentration of 90%, filter, dry, pulverize, and sieve to obtain carboxymethyl-modified short amylose.

[0044] Table 1 The influence of volume concentration of ethanol solution on the properties of sho...

Embodiment 2

[0048] The effect of embodiment 2 sodium hydroxide addition amount on short amylose properties

[0049] (1) Use the ethanol solution with a volume concentration of 80% to adjust the short amylose solution into starch milk with a concentration of 10%;

[0050] (2) Under stirring state, add sodium hydroxide to described starch slurry, react, control reaction temperature to be 40 ℃, reaction time is 1h, the addition amount of sodium hydroxide is as shown in table 2;

[0051] (3) Add 2g of chloroacetic acid to the reaction system treated in (2), the time of adding chloroacetic acid is controlled at 10min, and the reaction temperature is 40°C;

[0052] (4) After etherification, adjust the pH value to 7.0 with hydrochloric acid, wash with ethanol with a volume concentration of 90%, filter, dry, pulverize, and sieve to obtain carboxymethyl-modified short amylose.

[0053] Table 2 The effect of sodium hydroxide addition on the properties of short amylose

[0054]

[0055] As can ...

Embodiment 3

[0056] The impact of embodiment 3 chloroacetic acid on the properties of short amylose

[0057] (1) Use the ethanol solution with a volume concentration of 80% to adjust the short amylose solution into starch milk with a concentration of 10%;

[0058] (2) under stirring state, add 2g sodium hydroxide to described starch slurry, react, control reaction temperature to be 40 ℃, reaction time is 1h;

[0059] (3) Add chloroacetic acid in the reaction system processed through (2), the time of adding chloroacetic acid is controlled at 10min, the reaction temperature is 40°C, and the addition amount of chloroacetic acid is as shown in table 3;

[0060] (4) After etherification, adjust the pH value to 7.0 with hydrochloric acid, wash with ethanol with a volume concentration of 90%, filter, dry, pulverize, and sieve to obtain carboxymethyl-modified short amylose.

[0061] Table 3 The effect of chloroacetic acid addition on the properties of short amylose

[0062]

[0063] It can be...

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Abstract

The invention discloses a preparation method and application of modified short-straight-chain starch, and belongs to the technical field of nano composite materials. The preparation method is characterized in that short-straight-chain starch is modified by chloroacetic acid, carboxyl is led into the short-straight-chain starch, and negative electric potential of the short-straight-chain starch isincreased. Carboxymethyl short-straight-chain starch is taken as a carrier, and chitosan is led in for embedding insulin, so that characteristics such as wide source, low price and high embedding rateare achieved, and very good effect can be achieved for embedding insulin. A preparation process for preparing carboxymethyl short-straight-chain is green and environmentally friendly, is gentle in reaction condition, is simple and practicable in process route, is easy for industrial operation, and has a large-scale popularization and application potential.

Description

technical field [0001] The invention relates to a preparation method and application of modified short amylose, belonging to the technical field of nanocomposite materials. Background technique [0002] With the rapid development of biotechnology, the variety and number of protein and polypeptide drugs represented by insulin are increasing day by day. Most of the preparations of protein and polypeptide drugs are injections, which are inconvenient in clinical use. The non-injection dosage forms of these drugs have been developed. It is of great significance to improve the safety, effectiveness and patient compliance of medication, and the oral administration of protein and peptide drugs is undoubtedly one of the most challenging research directions. Rapid advances in nanotechnology have opened up new avenues for oral delivery of insulin. Using nanoparticles as a drug carrier can effectively protect insulin from the degradation of gastric acid and gastrointestinal enzymes and...

Claims

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Application Information

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IPC IPC(8): C08B33/04A61K9/50A61K38/28A61K47/36A61P3/10
CPCA61K9/5036A61K38/28A61P3/10C08B33/04
Inventor 洪雁姬娜顾正彪程力李兆丰李才明石建中
Owner JIANGNAN UNIV
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