The invention relates to the filed of fiber manufacture, in particular to a fiber manufacture method of micro-nano powder comprising bismuth germinate. The invention uses polyester, polypropylene or nylon as base material which comprises 1 percent to 50 percent of multielement mixing ultra-fine powder by weight percentage, and the multielement mixing ultra-fine powder comprises the following ingredients by the following weight percentage: 1 percent to 49 percent of bismuth germinate micro powder, 1 percent to 49 percent of tin dioxide, 1 percent to 2 percent of trace elements beneficial to human bodies, such as calcium, kalium, iron, zinc, silver, and the like, and the granularity of the trace elements is from 0.3 micron to 0.5 micron. After being sliced, the base material is stirred with the multielement mixing ultra-fine powder, wherein the weight percentage of the mixed ultra-fine powder in the base material slices is 1 percent to 50 percent, then 1 percent to 5 percent of a polymer spinning aid is added, melted and fully stirred for 20 minutes at a melting temperature of 260 DEG C to 286 DEG C, and the mixture is sprayed, cooled, fixed, curled, pulled to form the fibers comprising the bismuth germinate.