Anti-gout effect of tetrazole compounds
The technology of a compound and tetrazolium, which is applied in the field of anti-gout compounds, can solve the problems of large side effects and poor curative effect, and achieve the effects of low toxicity, rapid absorption and obvious effect.
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Embodiment 1
[0022] The preparation method that tetrazole compound is used for preparing composite oral soft capsule preparation comprises the following steps:
[0023] 1) Take 100g of the same batch of mulberry root, add 12 times the amount of water, decoct at 0.07MPa and 85°C for 45 minutes, then add 8 times the amount of water and decoct for 45 minutes under the same conditions, and combine the decoction , concentrated under reduced pressure to 150g, let cool to 37°C, and set aside; 2) Add new calcium oxide milk to the decoction under stirring to adjust the pH value to 9.8, let it stand for 10 hours, centrifuge, and suspend the sediment in 6 times the amount In 85% ethanol solution, adjust the pH value to 3.3 with sulfuric acid solution, stir fully to make the reaction complete, centrifuge, add sodium hydroxide solution to the centrifuged liquid to adjust the pH value to 6.8, filter, recover ethanol from the filtrate under reduced pressure, and evaporate the ethanol to the fullest, 60 C...
Embodiment 2
[0025] Tetrazolium compound is used for preparing composite oral soft capsule preparation, and its preparation method specifically comprises the following steps:
[0026] 1) Take 100g of the same batch of scorpion stalks, add 15 times the amount of water, decoct at 0.08MPa and 88°C for 60 minutes, then add 10 times the amount of water and decoct for 60 minutes under the same conditions, and combine the decoction , concentrated under reduced pressure to 180g, let cool to 39°C, and stand-by; the operation of reduced-pressure extraction is simple and the method is feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient and prevent the degradation of adenosine. At the same time, it will not affect the yield of total flavonoids in the extract and active ingredients;
[0027]2) Preparation of extract powder: add fresh calcium oxide milk to the decoction under stirring to adjust the pH value to 10, leave it f...
Embodiment 3
[0030] The preparation method of the tetrazole compound for preparing the compound oral soft capsule preparation comprises: extracting, preparing extract powder, and preparing soft capsule, specifically including the following steps:
[0031] Extraction: Take 100g of the same batch of scorpion stalks, add 14 times the amount of water, decoct at 0.075MPa and 86°C for 60 minutes, then add 10 times the amount of water and decoct for 45 minutes under the same conditions, and combine the decoction , concentrated under reduced pressure to 150g, let cool to 38°C, and stand-by; the operation of reduced-pressure extraction is simple and the method is feasible, and the reduced-pressure extraction of Kudiezi can significantly increase the yield of adenosine in the active ingredient and prevent the degradation of adenosine. At the same time, it will not affect the yield of total flavonoids in the extract and active ingredients;
[0032] Preparation of extract powder: add fresh calcium oxi...
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