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Medicine delivery system for combined precise treatment of breast cancer and application thereof

A drug delivery system, breast cancer technology, applied in the direction of antineoplastic drugs, drug combinations, pharmaceutical formulations, etc., can solve the problems of low drug loading and limited application, and achieve strong near-infrared absorption, drug loading and encapsulation efficiency High and reduce the effect of systemic side effects

Inactive Publication Date: 2018-09-18
闫金银
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, graphene nanosheets mainly adsorb insoluble drug molecules through non-covalent bonding such as π-π interactions, and the drug loading capacity is low, which limits its application in the field of biomedicine.

Method used

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Embodiment Construction

[0022] The present invention is described in detail below in conjunction with embodiment.

[0023] The drug delivery system for combined precise treatment of breast cancer given in this example is composed of polyethylene glycol-modified mesoporous silicon-graphene nanosheets-ferric oxide drug delivery carrier and chemotherapy drugs, specifically:

[0024] Using ferroferric oxide as the magnetic ligand, mesoporous silicon-graphene nanosheets (GS) as the basic carrier, and the hydrophilic polymer polyethylene glycol (referred to as PEG) to connect ferric oxide to construct drug delivery Carrier; the obtained drug delivery carrier forms a drug delivery system with a size of 50 to 200 nanometers with the insoluble small molecule chemotherapy drug doxorubicin (DOX), which is a mesoporous silicon-graphene nanosheet for combined precision treatment of breast cancer - ferric oxide-polyethylene glycol / doxorubicin (abbreviated (GS-PEG-IONP / DOX).

[0025] The mesoporous silicon-graphen...

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Abstract

The invention relates to a medicine delivery system for combined precise treatment of breast cancer and application thereof. Ferroferric oxide is used as a magnetic ligand; meso-porous silicon-graphene nano-sheets are used as basic carriers; medicine delivery carriers are obtained through hydrophilic polymers of polyethylene glycol; the medicine delivery carriers and an insoluble micromolecular chemotherapeutic medicine of adriamycin form a meso-porous silicon-graphene nano-sheet-ferroferric oxide-polyethylene glycol / adriamycin medicine delivery system. The system can be used for the combinedprecise treatment (combining chemotherapy and photothermal therapy) of the breast cancer; the death rate of the breast cancer cells can be obviously improved. Compared with the medicine delivery system built by the prior art, the medicine delivery system has the advantages that various advantages are integrated; the combined targeted treatment of the breast cancer chemotherapy and photothermal therapy can be realized; the toxic and side effects of the whole body can be reduced; the repeated and complicated medicine delivery can be avoided through good medicine release features; the complianceof patients is improved.

Description

technical field [0001] The invention relates to a drug delivery system for combined targeted therapy, in particular to a drug delivery system for combined precision therapy of breast cancer and its application. Background technique [0002] Existing data show that breast cancer has become the most common malignant tumor in women and one of the main causes of death in women. The current clinical standard treatment is combined chemotherapy and radiotherapy after surgical resection, but there are many types of breast cancer, and the prognosis of each type is different, resulting in unsatisfactory postoperative radiotherapy and chemotherapy effects, poor prognosis and relatively large side effects of chemotherapy. affect the patient's survival time. The main reason may be that the current chemotherapy still lacks precise targeting, the dose of the drug at the tumor site is insufficient, the systemic side effects are large, and the patient's compliance is poor. Studies have sho...

Claims

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Application Information

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IPC IPC(8): A61K47/04A61K47/10A61K47/02A61K31/704A61K41/00A61P35/00
CPCA61K31/704A61K41/0052A61K47/02A61K47/10A61P35/00A61K2300/00
Inventor 闫金银孟英胡万宁
Owner 闫金银
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