Compounds and uses thereof for treating atherosclerosis

A compound and composition technology, applied in the field of medicine, can solve the problems of niacin patients' compliance troubles, side effects, flushing, etc.
CN108546268BActive Publication Date: 2019-04-09XIAN PEIHUA UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XIAN PEIHUA UNIV
Publication Date
2019-04-09

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Abstract

The invention relates to a quinolinone compound for treating atherosclerosis, and an application of the compound in preparing medicine for treating atherosclerosis. The compound of the present invention can improve the uptake rate of liver cells for low-density lipoprotein LDL, can reduce serum total cholesterol (TC), serum triglyceride (TG), serum low-density lipoprotein cholesterol (LDL-C) of rats, shows The compound of the present invention can greatly reduce blood fat, so it can be used for preventing and treating atherosclerosis. Furthermore, the above-mentioned effects of the compounds of the invention are comparable or even superior to those of simvastatin.
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Description

technical field

[0001] The present invention relates to the field of medicine, in particular to a compound for treating atherosclerosis and the application of the compound in the preparation of medicine for treating atherosclerosis. Background technique

[0002] Atherosclerosis (AS) is a systemic disease related to lipid metabolism disorders, characterized by lipid deposition in the intima of large and medium arteries, atherosclerotic plaque formation, fibrous tissue hyperplasia, and arterial wall sclerosis. Atherosclerosis and its associated vascular complications are a major cause of cardiovascular and cerebrovascular diseases leading to heart attack and stroke. Over time, plaque deposits within the arteries increase in size, preventing oxygen from reaching downstream organs. When a vital artery in the heart becomes blocked, it can cause angina and heart attack, and can lead to death. Atherosclerosis also affects the arteries leading to the brain, causing blood clots in ...

Claims

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