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A simulation system for simulating fracture healing process

A fracture healing and simulation system technology, applied in the field of biomedical engineering, can solve the problems of not describing the angiogenesis process of fracture healing from different levels, not accurately establishing cell concentration, and not having fracture healing, so as to avoid humanitarian controversy and reduce Effect of delaying union and reducing fracture nonunion

Inactive Publication Date: 2019-12-10
HARBIN UNIV OF SCI & TECH
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  • Abstract
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  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to solve the problem that there is no fracture healing simulation system for special patients during the fracture healing process, the establishment of the fracture healing area model is too simplified, the angiogenesis process in the fracture healing process is not described from different levels, and the correlation in the fracture healing process is not accurately established. Due to the shortcomings of the relationship between cell concentration, related growth factor concentration and related cell extracellular matrix concentration over time, a simulation system for simulating the fracture healing process is proposed

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  • A simulation system for simulating fracture healing process
  • A simulation system for simulating fracture healing process
  • A simulation system for simulating fracture healing process

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specific Embodiment approach 1

[0036] Specific implementation mode one: as figure 1 As shown, a simulation system for simulating the fracture healing process described in this embodiment includes:

[0037] Fracture area analysis model establishment module 1, revascularization subsystem 2, fracture healing process modeling subsystem 3 and procedure termination judgment module 4;

[0038] Fracture area analysis model establishment module 1 is used to establish fracture area geometric model and finite element analysis model;

[0039] The revascularization subsystem 2 includes:

[0040] The modeling module of intracellular molecular physiological activities is used to model the revascularization process during fracture healing from the relevant molecular physiological activities at the intracellular molecular level;

[0041] The related molecules include angiogenesis cell growth factor receptor, Notch1 protein, Dll4 protein, activated angiogenesis cell growth factor receptor, activated Notch1 protein, effecti...

specific Embodiment approach 2

[0052] Specific implementation mode two: as Figure 1-4 As shown, in this embodiment, the specific process of the fracture area analysis model building module 1 to realize its function is:

[0053] 1) The establishment of a three-dimensional surface geometric model of the fracture area;

[0054] Using the segmentation-based 3D medical image surface reconstruction algorithm to reconstruct the surface of the image, and obtain the 3D surface geometric model through the process of threshold screening, interactive segmentation and 3D reconstruction;

[0055] The image is obtained by imaging equipment CT, and the data storage format is DICOM;

[0056] 2) Establishment of the finite element model of the fracture area;

[0057] Mesh the three-dimensional surface geometric model of the fracture area, discretize the continuous geometric model, and obtain the finite element model of the fracture area;

[0058] The meshing includes two steps of surface meshing and volume meshing: the sur...

specific Embodiment approach 3

[0063] Specific implementation mode three: as Figure 1-4 As shown, in this embodiment, the specific process for the revascularization subsystem 2 to realize its functions is as follows:

[0064] 1)Molecular physiological activity modeling module inside the cell

[0065] The process of angiogenic growth factor receptor activation is described as follows:

[0066]

[0067] In the formula, V t 'is the number of activated angiogenic growth factor receptors at time t, V sink is the number of angiogenic cell growth factor decoy receptors, t is time, δt is the cycle time of the subroutine, V t-δt is the number of angiogenic cell growth factor receptors at time t-δt, V max is the maximum number of angiogenic cell growth factor receptors, g vessel is the concentration of angiogenic cell growth factor, M tot is the total amount of angiogenesis cell membrane;

[0068] The modeling process of Dll4 protein quantity is as follows:

[0069] D. t =D t-δt +V″ t-δt δ-N' t-δt,nei...

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Abstract

The invention relates to a simulation system for simulating a fracture healing process and belongs to the biomedical engineering field. The invention aims to predict the complex process of fracture healing and explore an optimal fracture healing plan. The system includes a fracture region analysis model building module, a blood supply reconstruction subsystem, a fracture healing process modeling subsystem and a program termination judgment module; the fracture region analysis model building module is used for establishing a fracture region geometric model and a finite element model; the bloodsupply reconstruction subsystem is used for modeling the regenerative process of blood vessels from an intracellular molecular level and a cellular level; the fracture healing process modeling subsystem is used for modeling the fracture healing process from a tissue level; and the program termination judgment module is used for judging whether a program is terminated. According to the simulation system for simulating the fracture healing process of the invention, the fracture healing process is modeled from the intracellular molecular level, the cellular level and the tissue level, and therefore, the modeling of the fracture healing process can be improved, the fracture healing process can be simulated more accurately, and favorable help can be provided for the exploration of an optimal fracture healing treatment plan.

Description

technical field [0001] The invention relates to the field of biomedical engineering, in particular to a simulation system for simulating the fracture healing process. Background technique [0002] Fracture is a common trauma, and the high incidence of fracture makes the study of fracture healing mechanism and promotion of fracture healing particularly urgent. Unlike other tissue injuries, fractures are not connected by fibrous connective tissue, but complete regeneration of bone tissue. However, not all fractures heal completely and sometimes delayed union or even nonunion occurs. Delayed union or nonunion of fractures can cause pain and dysfunction in the affected limb, leading to unemployment of the patient, which causes a great social and economic burden. Therefore, although the research on fracture healing has been receiving much attention, there are still 5% to 10% of fractures with delayed union or even nonunion due to various reasons. [0003] Fracture healing is a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/50
CPCG16H50/50
Inventor 王沫楠杨宁
Owner HARBIN UNIV OF SCI & TECH
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