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Isolated organ protection liquid

An isolated organ and protective solution technology, applied in the field of organ transplantation, can solve the problems of high viscosity of hydroxyethyl starch, low cell membrane stability, high price, etc. Effect

Active Publication Date: 2018-10-12
上海理工资产经营有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, UW liquid still has the following defects. 1. The viscosity of hydroxyethyl starch is too high, which is not conducive to perfusion
2. Cell membrane stability is low 3. Expensive

Method used

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Embodiment 1

[0024] An isolated organ protection solution, the specific formula is shown in Table 1:

[0025] Table 1 Composition of isolated organ protection solution

[0026] ingredient

content

Polyvinyl alcohol (PVA)

1g / L

Trehalose

0.005g / L

Histidine

0.09mol / L

Sodium hydroxide (0.05mol / L)

4-6ml

Potassium hydroxide (0.005mol / L)

19-21ml

Adenosine

0.006mol / L

Allopurinol

0.001mol / L

Glutathione

0.003mol / L

Potassium Dihydrogen Phosphate

0.025mol / L

Magnesium Sulfate

0.005mol / L

Dexamethasone

8mg / l

[0027] The preparation method is as follows:

[0028] Use an electronic balance to accurately weigh the above formula drugs, dissolve them in an appropriate amount of sterile distilled water (about 700ml), add distilled water to a sufficient amount (1000ml), and measure the pH, osmotic pressure, and ion concentration. The above-mentioned preparation process is carried out under aseptic conditions and sterilized by sterile filtration. This organ protection solution must be...

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Abstract

The invention relates to isolated organ protection liquid. The protection liquid takes water as a solvent and is prepared from the following components with the mass concentration or the mol concentration: a cell swelling inhibitor with the concentration of 0.8 to 1.6g / L, a cell membrane stabilizing agent with the concentration of 0.01 to 0.015g / L, adenosine with the concentration of 0.005 to 0.008mol / L, allopurinol with the concentration of 0.001 to 0.002mol / L, glutathione with the concentration of 0.001 to 0.005mol / L, an H<+> buffering agent with the concentration of 0.1 to 0.12mol / L and magnesium sulfate with the concentration of 0.003 to 0.006mol / L, wherein the cell swelling inhibitor is prepared from polyvinyl alcohol, potassium hydroxide and sodium hydroxide. Compared with the priorart, the solution viscosity is reduced, a cell membrane is protected and the production cost is reduced.

Description

Technical field [0001] The invention relates to organ transplantation technology, in particular to an isolated organ protective liquid. Background technique [0002] The organ preservation solution is of great significance for improving the utilization rate of organs and thus the success rate of transplantation operations. Belzer et al. believe that the protective solution must meet the following six points if it wants to successfully preserve isolated organs: 1. Reduce cell edema caused by cryopreservation; 2. Prevent acidification of cells; 3. Prevent cell gap expansion during lavage storage 4. Prevent or reduce reperfusion injury; 5. Provide substrates for regeneration and high-energy phosphorylation synthesis; 6. Keep the intracellular environment stable. [0003] At present, the most used organ preservation liquid in hospitals is UW liquid, designed by Belter, and it has been confirmed that the liver, kidney and other isolated organs preserved with it have good clinical appli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N1/02
CPCA01N1/0221A01N1/0226
Inventor 蒋沛刘宝林宋晓燕火晓月宋作黄智勇
Owner 上海理工资产经营有限公司
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