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A three-dimensional interpenetrating network scaffold based on graphene and 58S bioactive glass and its application

A bioactive glass and interpenetrating network technology, applied in the field of biological tissue engineering scaffold materials, can solve the problems of low fracture toughness, hindering the application of biological tissue scaffolds, poor wear resistance, etc., and achieve good electrical conductivity and mechanical properties, good three-dimensional Effect of microenvironment, good biocompatibility

Active Publication Date: 2021-02-19
WENZHOU MEDICAL UNIV
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  • Application Information

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Problems solved by technology

However, in the existing prior art, the poor wear resistance and relatively low fracture toughness of bioactive glass itself hinder its application as a biological tissue scaffold

Method used

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  • A three-dimensional interpenetrating network scaffold based on graphene and 58S bioactive glass and its application
  • A three-dimensional interpenetrating network scaffold based on graphene and 58S bioactive glass and its application
  • A three-dimensional interpenetrating network scaffold based on graphene and 58S bioactive glass and its application

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Embodiment Construction

[0041] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0042] Preparation Example

[0043] (1) Preparation of GF / 58S BG three-dimensional interpenetrating network scaffold

[0044] a. Nickel foam (Ni foam) as raw material, CH 4 as the gas source, in N 2 / H 2 Under the atmosphere, Ni-G composite scaffolds were prepared by CVD method (by changing the CH 4 Gas flow, ventilation time and CH 4 :H 2 ratio, optimize the preparation conditions of GF scaffold);

[0045] The obtained Ni-G composite scaffold was added dropwise with 4% polymethylmethacrylate (PMMA) solution, dried at 180 °C for 30 min, and then diluted with HNO 3 / H 2 O 2 Ni was removed from the mixed solution to obtain GF-PMMA composite scaffold material. The GF-PMMA composite scaffold material was soaked in acetone solution at 50 °C to remove P...

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Abstract

The invention discloses a three-dimensional interpenetrating network stent on the basis of graphene and 58S bioactive glass and application of the three-dimensional interpenetrating network stent. Thetechnical scheme includes that foam nickel is used as a growth matrix, and accordingly graphene / bioactive glass composite materials with three-dimensional interpenetrating network structures can be prepared from the growth matrix and the bioactive glass by the aid of chemical vapor deposition (CVD) methods. The three-dimensional interpenetrating network stent and the application have the advantages that GF (graphene) / 58S BG (bioactive glass) interpenetrating network constitution is favorable for effectively combining the excellent electric conductivity and mechanical properties of the graphene and the excellent biocompatibility of the bioactive glass with one another, and accordingly excellent three-dimensional micro-environments can be provided to adhesion and stimulation growth of mesenchymal stem cells [rMSCs (rat mesenchymal stem cells)].

Description

technical field [0001] The invention belongs to the field of biological tissue engineering scaffold materials, and specifically refers to a three-dimensional interpenetrating network scaffold based on graphene and 58S bioactive glass and its application. Background technique [0002] According to statistics, about 13 million fractures occur in China every year, of which 10-15% cannot heal. In addition, there are as many as one orthopedic surgery due to joint replacement surgery, trauma, abnormal bone development or other reasons every year. In this million operations, about 450,000 operations require bone grafting, and with the increase of population and the extension of human life expectancy, this number is still rising . Currently, the repair of large bone defects caused by trauma, tumor resection, infection, and congenital malformations is a major clinical challenge. At present, the treatment of large bone defects mainly depends on transplantation, including autologous ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/08A61L27/12A61L27/56A61L27/58
CPCA61L27/08A61L27/12A61L27/56A61L27/58A61L2430/02
Inventor 姚清清郑晓刘瑜程如梅林蜜蜜
Owner WENZHOU MEDICAL UNIV
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