Application of short peptide to preparation of immunoregulation medicament

A short peptide and drug technology, applied in the field of biomedicine, can solve the problems of poor stability and shortened half-life
CN108690123AActive Publication Date: 2018-10-23SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
Publication Date
2018-10-23

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Abstract

The invention relates to application of a short peptide miPEP155 to preparation of an immunoregulation medicament. The short peptide is derived from a host gene of micro RNA155, and is named as miPEP155. The miPEP155 polypeptide can restrain the differentiation of Th17 cells, has an immunoregulation function, and can be used for preventing or treating autoimmune diseases.
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Description

technical field

[0001] The invention belongs to the field of biomedicine, and more specifically, the invention relates to the application of short peptide miPEP155 in the preparation of immunomodulatory drugs. Background technique

[0002] Th17 cells (T helper cell17, Th17) are a newly discovered T cell subset capable of secreting interleukin 17 (interleukin 17, IL-17), Th17 is differentiated by T0 cells under the stimulation of IL-6 and IL-23 Helper T cells, RORγ is an important transcription factor. Th17 cells can secrete and produce IL-17A, IL-17F, IL-6 and tumor necrosis factor a (tumor necrosis factora, TNF-a), etc. These cytokines can collectively mobilize, recruit and activate neutrophils, thus effectively It mediates the inflammatory response of tissues, so Th17 plays an important role in autoimmune diseases and body defense responses.

[0003] Studies have shown that Th17 is closely related to autoimmune diseases such as psoriasis, autoimmune encephalitis, asthma,...

Claims

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