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Method for detecting multiple antiseptics in cosmetics

A method of determination and technology of cosmetics, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of turbidity, inapplicability, and poor specificity of the solution to be tested, and achieve simple and convenient operation, short analysis time, and high efficiency Effect

Active Publication Date: 2018-10-23
伯德创研(广州)生物科技有限公司
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Problems solved by technology

There are many kinds of preservatives that can be detected by liquid chromatography, and the pretreatment is relatively simple. However, due to the poor specificity of detectors such as ultraviolet light, the target compound is easily interfered by liquid chromatography.
At present, when detecting preservatives in cosmetics and other products, the pretreatment method mainly adopts ultrasonic extraction with organic solvents, filters or centrifuges with organic membranes, and takes the supernatant for direct detection, but the above methods are not suitable for semi-solid samples such as creams and creams Not applicable, there are often cases where the test solution cannot be filtered or the filter membrane absorbs a large amount of target compounds or the test solution is still turbid after centrifugation, and some target compounds

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  • Method for detecting multiple antiseptics in cosmetics

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Embodiment 1

[0031] The content of 14 kinds of preservatives in cosmetics is detected by the method of the present invention.

[0032] Instrument: Agilent 6890N gas chromatograph equipped with flame ionization detector (FID), TB-114 analytical balance, Dima ProElut TPC solid phase extraction column.

[0033] Standards: Benzoic Acid, Sorbic Acid, Dehydroacetic Acid, Methylparaben, Benzylparaben, Benzyl Alcohol, Phenoxyethanol, O-Phenylphenol, Triclosan, Triclocarban, Methylparaben Chlorisothiazolinone, bronopol, chlorphenesin and iodopropynyl butyl carbamate (both purity>99.0%); tetrahydrofuran, methanol, ethyl acetate (chromatographically pure).

[0034] Cosmetics to be tested: Moisturizer.

[0035] Pre-treatment process: Weigh 2.0g of moisturizer sample, put it in a separatory funnel, add 50mL of tetrahydrofuran, add 10mL of saturated NaCl solution, acidify 1mL of HCl(1+1) solution, fully shake and extract, stand still, and separate layers ; After the stratification is complete, release...

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Abstract

The invention discloses a method for detecting multiple antiseptics in cosmetics. The antiseptics are: benzoic acid, sorbic acid, dehydroacetic acid, methyl paraben, benzyl paraben, benzyl alcohol, phenoxyethanol, o-phenyl phenol, triclosan, triclocarban, methylchloroisothiazolinone, bronopol, chlorphenesin, and iodopropynyl butylcarbamate. The method comprises following steps: tetrahydrofuran liquid-liquid extraction, solid phase extraction column purification, and gas chromatography separation and analysis. The results of tests show that the provided method is suitable for many cosmetics onthe market and can accurately detect antiseptics in the cosmetics.

Description

technical field [0001] The invention relates to a method for measuring preservatives, in particular to a method for determining the content of various preservatives in cosmetics. Background technique [0002] Since various nutrients are added to cosmetics, and these nutrients are the culture medium for microbial reproduction, during the production, use and storage of cosmetics, they may be polluted by bacteria, which may cause the product to produce odor or change appearance. In order to inhibit bacteria A certain amount of preservatives are added to the product, but frequent contact will cause adverse effects on human health. [0003] my country's "Hygienic Standards for Cosmetics" regards it as a restricted substance and stipulates the use limit of 56 kinds of preservatives. The determination of the content of preservatives in cosmetics is a quick, simple and direct means to evaluate the use of cosmetic preservatives. At present, the literature reports that the detection...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06
Inventor 马梅伍
Owner 伯德创研(广州)生物科技有限公司
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