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Application of arctigenin in preparation of medicine for treating chronic atrophic gastritis

A technology of arctigenin and atrophic gastritis, which is applied in the field of medicine to achieve the effect of reducing atrophy, increasing the thickness of the gland, improving the therapeutic effect and quality of life

Pending Publication Date: 2018-11-02
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, there is no relevant report on treating chronic atrophic gastritis with arctigenin

Method used

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  • Application of arctigenin in preparation of medicine for treating chronic atrophic gastritis
  • Application of arctigenin in preparation of medicine for treating chronic atrophic gastritis
  • Application of arctigenin in preparation of medicine for treating chronic atrophic gastritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Embodiment 1 arctigenin injection

[0016]

[0017] Preparation process: mix the prescribed amount of PEG-400 with ethanol, add arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 10000ml, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 2

[0018] Embodiment 2 arctigenin injection

[0019]

[0020] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add arctigenin, stir to dissolve, add water for injection to 10,000ml, stir evenly, add 0.5% activated carbon for needles, stir for decarbonization, and then divide and pack.

Embodiment 3

[0021] Embodiment 3 arctigenin injection

[0022]

[0023]

[0024] Preparation process: Mix the prescribed amount of propylene glycol and ethanol evenly, add arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% needles, stir with activated carbon, decarbonize, and then pack it. .

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Abstract

The invention belongs to the field of medicines, relates to medicinal use of arctigenin, and particularly relates to application of arctigenin in preparation of a medicine for treating chronic atrophic gastritis. A research proves that by adopting the arctigenin disclosed by the invention, pathological change of chronic atrophic gastritis model gastric epithelial in rats can be reduced, the atrophy is obviously alleviated, and the serum gastrin level is improved. According to the arctigenin disclosed by the invention, the thickness of glandular organs can be increased, the number of the glandular organs is increased, the inflammatory index is reduced, and the serum gastrin level is improved. The arctigenin has the advantages of definite curative effects and low toxic and side effects whilebeing used for treating the chronic atrophic gastritis; therefore, the arctigenin has wide application prospects.

Description

technical field [0001] The invention relates to the use of arctigenin in the preparation of medicines for treating chronic atrophic gastritis, which belongs to the field of medicine. Background technique [0002] Chronic atrophic gastritis (CAG) is a common and intractable disease of the digestive system, and an important precancerous disease of the stomach (the annual canceration rate is 0.5% to 1%). Reduced or disappeared, the clinical manifestations are fullness or pain in the epigastric cavity, heating, noise, loss of appetite, weight loss, etc., which belong to the category of syndromes such as fullness, noise, and stomach pain in traditional Chinese medicine. It has long been believed that the occurrence of chronic atrophic gastritis is the result of the combined effects of various factors, such as Helicobacter pylori infection and peptic ulcer, and it is also related to its activity change and repeated refractory. Reactivity, bile reflux, autoimmunity, genetics, age,...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P1/04
CPCA61K31/365Y02A50/30
Inventor 张贵民姜明敏宫海蕊
Owner LUNAN PHARMA GROUP CORPORATION
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