A method for controlling the effect of hydrophilic modification inside a microfluidic chip

A microfluidic chip and control method technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problem of difficult to directly characterize microfluidic chip pores, and difficult to represent the hydrophilic modification of pores. The real level of the effect and other issues, to achieve the effect of stable results, short marking time, and rapid response
CN108722506BActive Publication Date: 2020-05-19BEIJING UNIV OF CHEM TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING UNIV OF CHEM TECH
Publication Date
2020-05-19

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Abstract

The invention provides a method for controlling the hydrophilic modification effect inside a micro-fluidic chip, and belongs to the technical field of micro-fluidic chip hydrophilic control. The method is based on the specific and selective recognition effects of aggregation induction luminescent molecules modified by two boric acid groups and PVA containing hydroxyls, the fluorescence visual imaging labeling is performed inside the micro-fluidic chip subjected to hydrophilic treatment; the inside fluorescence intensity and distribution condition can be subjected to measurement and control condition analysis through a fluorescence microscope or a laser co-focusing microscope. The method has the advantages that the in-situ visual control on the micro pore passages in the micro-fluidic chipis realized; the problem that the in-situ detection cannot be realized on the inside of the chip in the conventional measurement can be solved; the method belongs to a safe, nondestructive, fast and effective visual recognition method, and can be widely applied to the materials to realize the fast screening on the hydrophilic treatment effects.
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Description

technical field

[0001] The invention belongs to the technical field of hydrophilization of microfluidic chips, and in particular relates to a method for specific identification, dyeing and fluorescence imaging control of hydrophilized and modified elastic PDMS chips. Background technique

[0002] Microfluidic chips have attracted attention because they can simultaneously realize sample preparation, separation, and detection in a micron-scale environment. Due to its advantages of high accuracy, good sensitivity, and less amount of reactants, it is widely used in the fields of chemistry, biology, and the environment. Among them, polydimethylsiloxane (PDMS) is due to its good optical transparency, simple preparation, and excellent elasticity. And other characteristics have become the main production materials of microfluidic chips. In order to play the important role of PDMS microfluidic chip in the sample reaction system, it is of great significance to hydrophilize its surfac...

Claims

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