Preparation method of antibacterial dressing with slow release effect and product thereof

Abstract

The invention provides a preparation method of antibacterial dressing with a slow release effect and a product thereof. The preparation method of the antibacterial dressing with the slow release effect comprises the steps that 1, carboxymethyl chitosan, macromolecular collagen and a carboxyl-containing antibiotic are mixed; 2, mixed liquid is poured into a mould for standing and drying to obtain an uncross-linked spongy material; 3, the uncross-linked spongy material is soaked in an absolute ethyl alcohol solution containing EDC/NHS for room temperature cross-linking to obtain the antibacterial dressing. According to the method and the product, by using a mode of which carboxyl on the antibiotic and amino on a compound dressing matrix are subjected to covalent bonding to form amido bonds,the condition that the antibiotic is grafted on the dressing matrix is achieved, through slow breakage of the amido bonds on a polymer skeleton, slow release of the antibiotic in the dressing is achieved, and thus the antibacterial dressing which has higher biocompatibility and long-term antibacterial activity and promotes wound healing is prepared.

Description

technical field [0001] The invention relates to a wound dressing, in particular to a preparation method of an antibacterial dressing with slow-release effect and its product. Background technique [0002] In order to avoid wound infection, wound dressings should have good antibacterial activity. An ideal antimicrobial dressing would effectively kill bacteria or fungi in wound infections, prevent bacterial biofilm formation, and prevent wound reinfection during healing, wound inspection, surgery, or dressing changes. However, the current commonly used antibacterial dressing preparation method is to physically mix small molecule drugs in the material (for example, the Chinese patent with the authorized announcement number CN201337582 discloses a method of adding ciprofloxacin to chitosan glue by physical mixing. method for preparing chitosan antiseptic dressings), which provides a viable option for the treatment of wound infections. However, because the antibacterial drugs o...

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However, the toxicity of these nanomaterials cannot be ignored. Studies have shown that nanosilver has obvious damage to various organs such as the spleen, liver and kidneys.

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