Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of composite fiber for artificial anterior cruciate ligament and its preparation method and application

A technology of anterior cruciate ligament and composite fiber, which is applied in the field of composite fiber of artificial anterior cruciate ligament and its preparation, can solve the problems of insufficient ligament strength, poor cell affinity, and low wear resistance, and achieve strong cell affinity , Good tissue compatibility and high wear resistance

Active Publication Date: 2021-04-16
佛山市第五人民医院 +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the LARS ligament composed of hydrophobic polyethylene terephthalate fibers still has its own inherent defects, such as insufficient strength of the ligament, low wear resistance, poor cell affinity, etc. (Bernardino S.ACL prosthesis: anypromise for the future [J]. Knee Surg. Sport. Tr. A., 2010, 18(6): 797-804.)

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of composite fiber for artificial anterior cruciate ligament and its preparation method and application
  • A kind of composite fiber for artificial anterior cruciate ligament and its preparation method and application
  • A kind of composite fiber for artificial anterior cruciate ligament and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Weigh polyhydroxybutyrate (purchased from Dongguan Suzhan Plastic Co., Ltd., with a number average molecular weight of 1.9×10 5 ) and polyglycolic acid (purchased from Shenzhen Boli Biomaterials Co., Ltd., with a number average molecular weight of 55,000), vacuum-dried at 50°C for 12 hours, and set aside.

[0039] (2) Add the polyhydroxyhexyl butyrate and polyglycolic acid dried in step (1) into deionized water at a mass ratio of 1:1, and heat to 80°C for 3 hours at a stirring speed of 500r / min , fully dissolved, and then filtered under reduced pressure, defoaming at 70° C. for 1 h in a vacuum state to obtain a mixed solution with a total solute concentration of 2 wt.%, which is ready for use.

[0040] (3) adopt dry spinning technology, the mixed solution in the step (2) is extruded solution trickle from spinneret capillary hole and enters spinning tunnel, passes through the hot air in the tunnel (the mixed gas of air and steam, The flow rate ratio of the two is 1:...

Embodiment 2

[0043] (1) Weigh polyhydroxybutyrate (purchased from Dongguan Suzhan Plastic Co., Ltd., with a number average molecular weight of 2.0×10 5 ) and polyglycolic acid (purchased from Shenzhen Boli Biomaterials Co., Ltd., with a number average molecular weight of 58,000), vacuum-dried at 50°C for 18 hours, and set aside.

[0044] (2) Add polyhydroxybutyrate and polyglycolic acid dried in step (1) to absolute ethanol at a mass ratio of 1:2, and heat to 85°C under reflux at a stirring speed of 550r / min 4h, fully dissolved, then vacuum filtration, degassing at 75°C for 1h in a vacuum state, to obtain a mixed solution with a total solute concentration of 3wt.%, ready for use.

[0045] (3) adopt dry spinning technology, the mixed solution in the step (2) is extruded solution trickle from spinneret capillary hole and enters spinning tunnel, passes through the hot air in the tunnel (the mixed gas of air and water vapor, The flow rate ratio of the two is 1:10), so that the solvent in the ...

Embodiment 3

[0048] (1) Weigh polyhydroxybutyrate (purchased from Dongguan Suzhan Plastic Co., Ltd., with a number average molecular weight of 2.1×10 5 ) and polyglycolic acid (purchased from Shenzhen Boli Biomaterials Co., Ltd., with a number-average molecular weight of 61,000), vacuum-dried at 50°C for 24 hours, and set aside.

[0049] (2) Add polyhydroxybutyrate and polyglycolic acid after drying in step (1) to dimethylacetamide at a mass ratio of 1:3, and heat to 85 at a stirring speed of 600r / min. Reflux at ℃ for 6 hours to fully dissolve, then filter under reduced pressure, defoam at 75℃ for 1.5 hours under vacuum to obtain a mixed solution with a total solute concentration of 4wt.%, which is ready for use.

[0050] (3) adopt dry spinning technology, the mixed solution in the step (2) is extruded solution trickle from spinneret capillary hole and enters spinning tunnel, passes through the hot air in the tunnel (the mixed gas of air and water vapor, The flow rate ratio of the two is ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the field of biomaterials, and discloses a composite fiber for artificial anterior cruciate ligament, a preparation method and application thereof. In the present invention, polyhydroxyhexyl butyrate and polyglycolic acid are composited, and the obtained composite fiber combines the advantages of both, and has both the good biocompatibility of polyhydroxybutyrate and polyglycolic acid Endowed with excellent physical and mechanical properties and cell affinity and other properties. In addition, based on the synergistic reinforcement mechanism, the composite fiber has superior performance than the single component. When the composite fiber is used to prepare the artificial anterior cruciate ligament, the new composite ligament exhibits the characteristics of strong wear resistance, good tissue compatibility and cell affinity, and high mechanical properties, which can meet the basic requirements of the artificial anterior cruciate ligament .

Description

technical field [0001] The invention belongs to the field of biomaterials, in particular to a composite fiber used for artificial anterior cruciate ligaments, a preparation method and application thereof. Background technique [0002] Anterior cruciate ligament injury is one of the most common types of knee ligament injuries in daily life and sports. In addition, it is difficult to heal itself after injury, and conservative treatment is basically ineffective, and the functional recovery is incomplete. In this regard, the treatment method is generally anterior cruciate ligament reconstruction, and there are usually three types of grafts available for it: autologous tendon, allogeneic tendon and artificial ligament. For autologous tendon, it is widely used, but there is the possibility of complications such as graft defect and postoperative pain; for allogeneic tendon, it can avoid sacrificing autologous tendon tissue, but there are limited sources, disease transmission, immu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/50A61L27/18D01F8/14
CPCA61L27/18A61L27/50A61L2430/10D01F8/14C08L67/04
Inventor 于绍斌蔡祥吴婷张劲林向卫兵
Owner 佛山市第五人民医院
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com