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A kind of preparation method and device of nanoscale dispersion liquid

A dispersion liquid and nano-scale technology, which is applied in mixing methods, chemical instruments and methods, transportation and packaging, etc., can solve the problems of limited preparation volume, discontinuous preparation process, and increased particle size of nanoparticles, so as to avoid excessive dilution, Realize the effect of mass production and particle size improvement

Active Publication Date: 2020-09-08
YANGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The secondary growth of nanoparticles may increase the particle size, broaden the distribution and decrease the stability of nanoparticles
At the same time, the secondary mixing is stirring and mixing, which leads to the discontinuity of the whole preparation process, it is difficult to ensure the consistency between batches of products, and the amount of each preparation is limited

Method used

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  • A kind of preparation method and device of nanoscale dispersion liquid
  • A kind of preparation method and device of nanoscale dispersion liquid
  • A kind of preparation method and device of nanoscale dispersion liquid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Such as figure 1 As shown, the nano-dispersion preparation device is equipped with a CIJ-L mixer with three inlets. The parts and operations in the device are represented by English letter codes, and the same parts are distinguished by numerical subscripts:

[0050] f O1 : organic phase solution,

[0051] f W0 , F W1 : aqueous solution,

[0052] C O1 :Organic solvents,

[0053] C W0 、C W1 :water,

[0054] V FO1 : organic phase storage tank,

[0055] V FW0 : circulating storage tank,

[0056] V FW1 : aqueous phase storage tank,

[0057] V CO1 : Organic solvent cleaning storage tank,

[0058] V CW0 , V CW1 : water cleaning storage tank,

[0059] V W : waste liquid storage tank,

[0060] SR 1 、SR 2 、SR 3 、SR 4 、SR F0 、SR W0 :Filter,

[0061] TV 0 、TV 1 、TV 2 、TV 3 :Three-way valve,

[0062] FV 0 、FV 1 、FV 2 :Four-way valve,

[0063] CHV 0 、CHV 1 、CHV 2 : check valve,

[0064] SV 0 :Shut-off valve,

[0065] P 0 ,P 1 ,P 2 :Pump, ...

Embodiment 2

[0080] Such as Figure 4 As shown, the nano-dispersion preparation device is equipped with a five-inlet CMIJ-L mixer. The parts and operations in the device are represented by English letter codes, and the same parts are distinguished by numerical subscripts:

[0081] f O1 , F O2 : organic phase solution,

[0082] f W0 , F W1 , F W2 : aqueous solution,

[0083] C O1 、C O2 :Organic solvents,

[0084] C W0 、C W1 、C W2 :water,

[0085] V FO1 , V FO2 : organic phase storage tank,

[0086] V FW0 : circulating storage tank,

[0087] V FW1 , V FW2 : aqueous phase storage tank,

[0088] V CO1 , V CO2 : Organic solvent cleaning storage tank,

[0089] V CW0 , V CW1 , V CW2 :: water cleaning tank,

[0090] V W : waste liquid storage tank,

[0091] SR 1 、SR 2 、SR 3 、SR 4 、SR 5 、SR 6 、SR 7 、SR 8 、SR F0 、SR C0 :Filter,

[0092] TV 0 、TV 1 、TV 2 、TV 3 、TV 4 、TV 5 :Three-way valve,

[0093] FV 0 、FV 1 、FV 2 、FV 3 、FV 4 :Four-way valve,

[0...

Embodiment 3

[0105] Prepare 150 mL of ethanol solution containing liquid tangerine essential oil (ACDlogP=4.4) (33uL / mL) and Tween 80 (67uL / mL) at room temperature, and place it in the organic phase storage tank V FO1 ; 150mL water is placed in the water storage tank V FW1 , 400mL water is placed in the circulation storage tank V FW0 Using the same method as in Example 1, after turning on the power supply and running the pump to exhaust the air, ethanol solution, water, and circulating fluid are simultaneously pumped into each feed port of the CIJ-L mixer with a flow ratio of 1:1:8. When the liquid circulates in the circulating storage tank for 100, 200, and 300 seconds (corresponding to 1, 1.8, and 2.5 cycles respectively, and obtains 3.3, 5.6, and 7.1 μg / mL tangerine essential oil nanoemulsion), take a few samples each and use dynamic light scattering tracking to measure the dispersion. The liquid particle size is 1 week, and the preparation is completed after a cycle of 300 seconds. O...

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Abstract

The invention discloses a method and device for preparing a nanoscale dispersion liquid. A hydrophobic compound is dissolved in an organic solvent as an organic phase. The organic phase is used as more than one strand of liquid and mixed with more than one strand of water phase at multiple inlets. The jet in the chamber of the mixer is continuously mixed to obtain the mixed liquid, and the mixed liquid flowing out of the chamber is continuously circulated and returned to the multi-inlet mixer chamber, and mixed with the organic phase and the water phase again until the dispersion liquid with a preset concentration is obtained and then flows out of the multi-inlet mixer to obtain nanoscale dispersions. The one-time rapid mixing and formation of nano-scale particles in the cavity of the present invention avoids the process of second dilution and mixing with the hydrophilic phase after the dispersion liquid flows out of the cavity, which leads to the secondary formation of particles, and improves the particle size of the dispersion liquid , distribution and stability; the use of cyclic mixing can provide a sufficiently large proportion of water content and supersaturation during mixing to ensure instantaneous and uniform formation of particles, while avoiding excessive dilution of the dispersion due to an excessive water ratio.

Description

technical field [0001] The invention relates to a method and device for preparing a nanoscale dispersion liquid, belonging to the field of nanomaterial preparation. Background technique [0002] Nanoscale dispersions such as nanoemulsions and nanosuspensions have large specific surface areas due to their small size, and exhibit excellent properties in terms of dissolution rate, viscosity, transparency, utility, and stability. It is widely used in medicine, food, mechanical processing, construction, printing and dyeing, petrochemical, daily chemical and other industries, and the demand is huge. Nanoemulsion is a multi-phase dispersion system formed by dispersing nano-droplets in another immiscible liquid, while suspension is a multi-phase dispersion system formed by dispersing nano-solid particles in a liquid . The conventional preparation methods of nanoemulsions and nanosuspensions: mechanical ball milling, high-pressure homogenization, and drop stirring methods have the ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01F3/08B01F5/02B01F5/10
CPCB01F23/45B01F25/20B01F25/50
Inventor 朱正曦王晓晓
Owner YANGZHOU UNIV
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