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Preparation method of amphipathic star-shaped block polymer with ultra-high pH stimulus-response

A technology of star-shaped polymer and block polymer is applied in the directions of non-active components of polymer compounds, medical preparations and pharmaceutical formulations of non-active components, etc., which can solve the problems of poor stability of nano-micelles and low drug loading capacity. , to achieve the effect of improving micelle stability and increasing drug loading

Inactive Publication Date: 2018-11-13
SOUTHWEST UNIVERSITY
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Problems solved by technology

[0006] However, the existing nanomicelles have poor stability and low drug loading, which are the key factors that have always restricted the development of this technology in the field of anticancer drugs.

Method used

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  • Preparation method of amphipathic star-shaped block polymer with ultra-high pH stimulus-response
  • Preparation method of amphipathic star-shaped block polymer with ultra-high pH stimulus-response
  • Preparation method of amphipathic star-shaped block polymer with ultra-high pH stimulus-response

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Embodiment Construction

[0025] The present invention will be further described below in conjunction with the accompanying drawings and specific embodiments.

[0026] Such as Figure 1 to Figure 5 Shown, a method for preparing an ultrahigh pH stimuli-responsive amphiphilic star-shaped block polymer comprises the following two parts:

[0027] The first part: Preparation of pH-sensitive β-CD-PPDA-POEGMA amphiphilic star polymer; this part is mainly used to synthesize amphiphilic materials to embed hydrophobic drugs, so as to realize the function and benefits of being a drug carrier.

[0028] The specific steps are as follows:

[0029] In the first step, cyclodextrin-based star atom radical polymerization (ATRP) initiator (CD-Br) was prepared: cyclodextrin (CD) and 2-bromoisobutyryl bromide were dissolved in 1-methyl React in pyrrolidone (NMP) for 48 hours, and purify to obtain the cyclodextrin (CD)-based star atomic radical polymerization (ATRP) initiator (CD-Br);

[0030]The second step is to prepar...

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Abstract

The invention discloses a preparation method of an amphipathic star-shaped block polymer with ultra-high pH stimulus-response. The preparation method is characterized by comprising the following steps: preparing a star-shaped atom radical polymerization reaction initiator based on cyclodextrin; preparing ultra-high pH sensitive star-shaped polymer; preparing an amphipathic star-shaped polymer; preparing a pH sensitive star-shaped polymer; preparing a pH sensitive amphipathic star-shaped polymer; and preparing an amphipathic star-shaped polymer loaded with near infrared fluorescent molecules. The drug loading capacity and stability of micelles can be improved, the sizes of nano micelles are changed, the problems of low drug load capacity of a current drug delivery system and selective controlled release of drugs are solved, and thus, accurate diagnosis and effective treatment of tumors become possible.

Description

technical field [0001] The invention relates to a method for preparing an ultra-high pH stimulus-responsive amphiphilic star-shaped block polymer. Background technique [0002] Doxorubicin (DOX) is an antitumor antibiotic, its CAS number: 23214-92-8, chemical structural formula: C27H29NO11, relative molecular weight: 543.52, can inhibit the synthesis of RNA and DNA, and has the strongest inhibitory effect on RNA It has a wide anti-tumor spectrum and has effects on a variety of tumors. It is a cycle non-specific drug and has a killing effect on tumor cells in various growth cycles. It is mainly applicable to acute leukemia, and is effective for acute lymphoblastic leukemia and myeloid leukemia. It is generally used as a second-line drug, that is, it can be considered when the first-line drug is resistant. Its mechanism of action is mainly that the drug intercalates into DNA and inhibits the synthesis of nucleic acid. [0003] Doxorubicin included in anticancer drug molecule...

Claims

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Application Information

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IPC IPC(8): C08F293/00C08F220/34C08F222/16C08F2/44A61K9/107A61K47/40A61K47/32
CPCA61K9/1075A61K47/32A61K47/40C08F2/44C08F220/34C08F222/1006C08F222/102C08F293/005C08F2438/01
Inventor 许志刚石潇潇马晓倩侯美丽康跃军
Owner SOUTHWEST UNIVERSITY
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