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A kind of multiple emulsion and its preparation method and application

A technology of multiple emulsions and solutions, applied in the fields of polymer materials and applied chemistry, can solve the problems of organic solvent residues and time-consuming, and achieve the effects of high stability, avoidance of removal steps, and simple preparation process.

Active Publication Date: 2021-05-11
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the safety requirements of raw materials in cosmetics, this method has the problem of residual organic solvents, and the process of removing organic solvents takes a long time, making it difficult to apply in practice.

Method used

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  • A kind of multiple emulsion and its preparation method and application
  • A kind of multiple emulsion and its preparation method and application
  • A kind of multiple emulsion and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Embodiment 1: multiple emulsion preparation

[0032] (1) Preparation of random polymer: the molar ratio of hydrophobic monomer lauryl methacrylate to hydrophilic monomer methacrylic acid is 1:4, the initiator is azobisisobutyronitrile (2%), 1, 4-dioxane as solvent, reacted for 24h. Purify with diethyl ether as precipitant.

[0033] (2) Preparation of random polymer solution: Dissolve an appropriate amount of random polymer prepared in step (1) in 0.05M sodium hydroxide solution, wherein the concentration of random polymer is 5 mg / mL, and wait until it is completely dissolved Leave overnight. The resulting polymer solution was adjusted to pH 7.0 with citric acid.

[0034] (3) Mix the water phase of step (2) with caprylic acid / capric triglyceride in a ratio of 1:4 and heat to 60°C to emulsify with a high-speed disperser at a speed of 10000r / min and shear for 5min.

[0035] The stability of the multiple emulsions prepared above was tested by freezing at -18°C for 24 ho...

Embodiment 2

[0037] Embodiment 2: multiple emulsion preparation

[0038] (1) Preparation of random polymer: the molar ratio of hydrophobic monomer octadecyl methacrylate to hydrophilic monomer methacrylic acid is 1:9, the initiator is azobisisobutyronitrile (1.5%), 1, 4-dioxane as solvent, reacted for 24h. Purify with diethyl ether as precipitant.

[0039] (2) Preparation of random polymer solution: Dissolve an appropriate amount of random polymer prepared in step (1) in 0.05M sodium hydroxide solution, wherein the concentration of random polymer is 5 mg / mL, and wait until it is completely dissolved Leave overnight. The resulting polymer solution was adjusted to pH 7.0 with citric acid.

[0040] (3) Mix the water phase of step (2) with jojoba oil in a ratio of 1:3, heat to 60°C and emulsify with a high-speed disperser at a speed of 10,000r / min and shear for 5min.

[0041] The stability of the multiple emulsions prepared above was tested by freezing at -18°C for 24 hours, returning to r...

Embodiment 3

[0042] Embodiment 3: multiple emulsion preparation

[0043] (1) Preparation of random polymer: the molar ratio of hydrophobic monomer lauryl methacrylate to hydrophilic monomer methacrylic acid is 1:19, the initiator is azobisisobutyronitrile (2%), 1, 4-dioxane as solvent (2%), reacted for 24h. Purify with diethyl ether as precipitant.

[0044] (2) Preparation of random polymer solution: Dissolve an appropriate amount of random polymer prepared in step (1) in 0.05M sodium hydroxide solution, wherein the concentration of random polymer is 5 mg / mL, and wait until it is completely dissolved Leave overnight. The resulting polymer solution was adjusted to pH 7.0 with citric acid.

[0045] (3) Mix the water phase of step (2) with caprylic acid / capric triglyceride in a ratio of 1:4 and heat to 60°C to emulsify with a high-speed disperser at a speed of 10000r / min and shear for 5min.

[0046] The stability of the multiple emulsions prepared above was tested by freezing at -18°C for 2...

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Abstract

The invention discloses a multiple emulsion and its preparation method and application, and belongs to the technical field of polymer materials and applied chemistry. In the present invention, the multiple emulsion is prepared by substituting a random polymer for the conventionally used lipophilic and hydrophilic emulsifiers. The multiple structure of the obtained emulsion is stable, the emulsion is uniform, and there is no stratification phenomenon after being placed at room temperature for one year. , and the high and low temperature cycle can still maintain stability for a week. Amphiphilic random polymers are prepared by copolymerizing hydrophobic and hydrophilic monomers. The copolymer can be directly dissolved and used in alkaline solution to effectively avoid the residue of organic solvents. Oil and other oil phases are mixed and sheared by a high-speed disperser to form multiple emulsions. The method is simple and fast to prepare, and successfully solves the cumbersome process of the multiple emulsion two-step process and the problems of the stability of the multiple emulsions. At the same time, the problem of skin irritation caused by surfactants in cosmetics is also solved, and can be used in large-scale industrial production.

Description

technical field [0001] The invention relates to a multiple emulsion and its preparation method and application, and belongs to the technical field of polymer materials and applied chemistry. Background technique [0002] Multiple emulsions, also known as complex emulsions, or multiple emulsions for short, were first discovered by Seifritz in 1825, but extensive research was not carried out until 1965. Multiple emulsions are multiple systems in which water-in-oil and oil-in-water emulsions coexist, and are generally highly dispersed systems with different particle sizes. There are mainly two types of W / O / W and O / W / O that are common in multiple emulsions. Multiple emulsions have many advantages and can be widely used in cosmetics, food, medicine and other industries, and have great development prospects. [0003] The most common methods for the preparation of multiple emulsions are two-step emulsification and membrane emulsification. The two-step emulsification method is us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/06A61K8/37A61K8/81A61Q19/00
CPCA61K8/066A61K8/375A61K8/8135A61K2800/10A61Q19/00
Inventor 曹玉华陈凯丽倪鑫炯曹光群
Owner JIANGNAN UNIV
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