Two-step method for preparing high-purity medium-chain and long-chain triglyceride

A triglyceride, medium and long chain technology, applied in the field of biopharmaceutical emulsifier preparation, can solve problems such as product purity reduction and acyl transfer, and achieve the effects of increasing content, ensuring activity, and improving yield

Inactive Publication Date: 2018-11-27
GUANGDONG JIABO PHARM CO LTD
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  • Description
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Problems solved by technology

However, in the one-step transesterification reaction, no matter how the reaction conditions are controlled, acyl transfer will inevitably occur, resulting in a reduction in the purity of the product.

Method used

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  • Two-step method for preparing high-purity medium-chain and long-chain triglyceride

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Embodiment 1

[0029] A method for preparing high-purity medium and long-chain triglycerides, the method and other process routes such as figure 1 shown, including the following steps:

[0030] (1) Place 8 g of immobilized enzyme Lipozyme435 on the carrying mechanism of the bubbling reactor, start the water bath mechanism to heat the reactor body to 70°C;

[0031] (2) Add 51g caprylic acid triglyceride (containing about 0.1mol medium-chain triglyceride) and 100g soybean oil (combining 0.1mol long-chain triglyceride) in the feed tank as reactants, and the reaction in the feed tank The material is preheated to 70°C, and then put into a bubbling reactor for transesterification reaction. Nitrogen is introduced into the reaction material and the nitrogen flow rate is controlled to be 2cm / s, so that the nitrogen gas is continuously blown into the main body of the reactor through the sieve plate, so that the material Mix well and carry out the transesterification reaction at a constant temperature...

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Abstract

The invention discloses a method for preparing high-purity medium-chain and long-chain triglyceride. The method is characterized by comprising the following steps: (1) adding immobilized enzyme into areactor, and preheating the reactor; (2) adding long-chain triglyceride and medium-chain triglyceride into a slot of the reactor as reaction materials, preheating, adding the reaction materials intothe reactor, adding a transesterification catalyst, introducing nitrogen, uniformly mixing the materials, and carrying out transesterification at a constant temperature; (3) carrying out molecular distillation on a product mixture of the transesterification, so as to obtain medium-chain and long-chain triglyceride; (4) putting medium-chain and long-chain triglyceride obtained in the step (3) and medium-chain fatty acid into the reactor containing immobilized enzyme, adding an activating enzyme catalyst, introducing nitrogen, and carrying out acidolysis on the mixed material at a constant temperature; and (5) distilling and refining an acidolysis reaction product obtained in the step (4), so as to obtain medium-chain and long-chain triglyceride. The method for preparing medium-chain and long-chain triglyceride is high in catalysis speed and enzyme reutilization rate and suitable for preparing high-purity medium-chain and long-chain triglyceride.

Description

technical field [0001] The invention belongs to the field of biopharmaceutical emulsifier preparation, and in particular relates to a method for preparing high-purity medium- and long-chain triglycerides. Background technique [0002] Medium- and long-chain triglycerides are products obtained by esterification of glycerol and three fatty acids. They have many advantages such as safety, nutrition, good processing suitability, and high human compatibility. They are a kind of multifunctional additives. It is widely used in food, medicine and chemical industries. [0003] Medium- and long-chain triglycerides can be prepared by biological enzyme catalysis. The most commonly used process route for enzymatically synthesizing medium and long-chain triglycerides is the transesterification method. The reaction principle of the transesterification method is to participate in enzymatic deacylation or water During the hydrolysis of triglycerides, intermediate diglycerides will be formed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P7/64
CPCC12P7/6454
Inventor 蔡文坚曾少群岳峰谢春燕
Owner GUANGDONG JIABO PHARM CO LTD
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