Soluble micro needle with anti-acne effect and preparation method thereof

A soluble, acne-removing technology

Active Publication Date: 2018-11-30
PROYA COSMETICS +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the methods of acne treatment mainly rely on the ingredients of acne medicines, such as benzoyl peroxide, retinoic acid, salicylic acid, benzalkonium chloride, antibiotics, etc. Retinoic acid, antibiotics are banned in cosmetics; salicylic acid, benzalkonium chloride has a clear low dosage limit
Therefore, the current commercially available anti-acne cosmetics have shortcomings such as lack of selection of functional ingredients, poor permeability of functional ingredients, and inconspicuous acne-removing effect; Easy-to-use acne products are essential

Method used

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  • Soluble micro needle with anti-acne effect and preparation method thereof
  • Soluble micro needle with anti-acne effect and preparation method thereof
  • Soluble micro needle with anti-acne effect and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] A method for preparing a soluble microneedle with anti-acne effect, characterized in that it comprises the following steps:

[0062] A. Weigh 800 g sodium hyaluronate at 8%, 100 g papain at 1%, 3000 g acne-removing composition at 30%, and 6100 g excipients at 61% for subsequent use; 100 g of chlorogenic acid, 200 g of licochalcone A, 1000 g of heparin sodium, and 1500 g of epigallocatechin gallate were weighed to form an acne-removing composition at a ratio of 1:2:10:15. Weigh 1000 g mannitol, 1000 g yeast dextran, 2000 g carboxymethylcellulose and 1000 g glycogen to form excipients respectively in a mass ratio of 1:1:2:1;

[0063] B. Mix and dissolve the acne-removing composition taken in step A with 14 kg of distilled water to obtain an aqueous solution of the acne-removing composition;

[0064] C. Dissolve the sodium hyaluronate weighed in step A in 79.2 kg distilled water to prepare a sodium hyaluronate aqueous solution with a mass fraction of 1%, then add the papa...

Embodiment 2

[0073] A method for preparing a soluble microneedle with anti-acne effect, characterized in that it comprises the following steps:

[0074] A. Weigh 10 g sodium hyaluronate at 10%, 3 g papain at 3%, 35 g acne-removing composition at 35%, and 52 g excipients at 52% for subsequent use; 15 g of chlorogenic acid, 45 g of licochalcone A, 180 g of heparin sodium, and 270 g of epigallocatechin gallate were weighed to form an acne-removing composition at a ratio of 1:3:12:18. Weigh 20 g mannitol, 40 g yeast dextran, 80 g carboxymethyl cellulose and 60 g glycogen to form the excipient respectively in a mass ratio of 1:2:4:3;

[0075] B. Mix and dissolve the acne-removing composition taken in step A with 500 g of distilled water to obtain an aqueous solution of the acne-removing composition;

[0076] C. Dissolve the sodium hyaluronate weighed in step A in 490 g distilled water to prepare a sodium hyaluronate aqueous solution with a mass fraction of 2%, then add the papain weighed in step...

Embodiment 3

[0085] A method for preparing a soluble microneedle with anti-acne effect, characterized in that it comprises the following steps:

[0086] A, take by weight 14% sodium hyaluronate 140g, 4% by weight 40g papain, 38% by weight 380g acne composition, 44% by weight by weight 440g excipient for subsequent use; 100 g of chlorogenic acid, 400 g of licochalcone A, 1500 g of heparin sodium, and 2500 g of epigallocatechin gallate were weighed to form an acne-removing composition at a ratio of 1:4:15:25. Weigh 100 g mannitol, 200 g yeast dextran, 500 g carboxymethyl cellulose and 400 g glycogen to form the excipient respectively in a mass ratio of 1:2:5:4;

[0087] B. Mix and dissolve the acne-removing composition taken in step A with 5000 g of distilled water to obtain an aqueous solution of the acne-removing composition;

[0088] C. Dissolve the sodium hyaluronate weighed in step A in 9193 g distilled water to prepare a sodium hyaluronate aqueous solution with a mass fraction of 1.5%...

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Abstract

The invention relates to a soluble micro needle with an anti-acne effect and a preparation method thereof. The micro needle comprises a substrate layer and a needle point arranged on the substrate layer. The micro needle is characterized in that the needle point is prepared from the following ingredients in percentage by mass: 8 to 15 percent of sodium hyaluronate, 1 to 5 percent of papain, 30 to40 percent of an anti-acne composition and the balance excipients; the anti-acne composition is prepared from chlorogenic acid, licochalcone A, lipo-hepinette, and epigallocatechin gallate according to the mass ratio of 1:(2 to 5):(10 to 18):(15 to 30); the substrate layer is prepared from polyvinylpyrrolidone. The prepared micro needle has the advantages of good anti-acne effect, use convenienceand the like.

Description

technical field [0001] The invention relates to a preparation method of a soluble microneedle in the technical field of cosmetics, in particular to a soluble microneedle with acne-removing effect and a preparation method thereof. Background technique [0002] Acne is an extremely common inflammatory skin disease of the pilosebaceous glands. Young people are prone to it. Genetic factors or imbalanced hormone secretion cause excessive sebum secretion, abnormal keratosis of hair follicles, and microbial infections. The main causes of acne are; air pollution, A high-fat diet and work stress are also possible causes of acne. [0003] At present, the methods of acne treatment mainly rely on the ingredients of acne medicines, such as benzoyl peroxide, retinoic acid, salicylic acid, benzalkonium chloride, antibiotics, etc. Retinoic acid and antibiotics are prohibited in cosmetics; salicylic acid and benzalkonium chloride have clear low dosage restrictions. Therefore, the current c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/02A61K8/35A61K8/37A61K8/49A61K8/66A61K8/73A61P17/10A61Q19/00
CPCA61K8/0204A61K8/35A61K8/375A61K8/498A61K8/66A61K8/73A61K8/735A61Q19/00A61P17/10
Inventor 李欣航蒋丽刚张金龙王玲毕永贤王晗宁
Owner PROYA COSMETICS
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