Tremella uronic acid polysaccharide-hibiscus plum anthocyanin complex for colon-targeted delivery and preparation method thereof

A tremella uronic acid polysaccharide and colon-targeting technology, which is applied in the field of food processing and can solve the problems of low bioavailability

Active Publication Date: 2021-09-28
福建省农业科学院农产品加工研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of low direct oral bioavailability of anthocyanins and difficulty in exerting health effects in the lower digestive tract (especially the colon), the present invention provides a tremella uronic acid polysaccharide-hibiscus plum anthocyanin complex and Its preparation method can reduce the damage of gastrointestinal tract environment and digestive enzymes to anthocyanins, thereby improving the bioavailability of anthocyanins in the human body

Method used

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  • Tremella uronic acid polysaccharide-hibiscus plum anthocyanin complex for colon-targeted delivery and preparation method thereof
  • Tremella uronic acid polysaccharide-hibiscus plum anthocyanin complex for colon-targeted delivery and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0018] (1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 100g of fruit powder, add it to 1500 mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min. crude anthocyanin extract; then the obtained crude anthocyanin extract was purified with AB-8 macroporous resin, washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, and the eluate was concentrated in vacuo at 45°C to remove ethanol, and then Vacuum freeze-drying to obtain hibiscus plum anthocyanins with an anthocyanin content of 950 mg / kg;

[0019] (2) Preparation of tremella uronic acid polysaccharide extract: Wash the discarded tremella fungus base, take 2...

Embodiment 2

[0023] (1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 300g of fruit powder, add 4500 mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min. crude anthocyanin extract; then the obtained crude anthocyanin extract was purified with AB-8 macroporous resin, washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, and the eluate was concentrated in vacuo at 45°C to remove ethanol, and then Vacuum freeze-drying to obtain hibiscus plum anthocyanins whose anthocyanin content is 837mg / kg;

[0024] (2) Preparation of tremella uronic acid polysaccharide extract: Wash the discarded tremella fungus base, take 400g of ti...

Embodiment 3

[0028](1) Preparation of hibiscus plum anthocyanins: select fresh hibiscus plums that are eight or nine mature, free from diseases and insect pests, and have bright red flesh, wash, remove pits, slice, dry with hot air at 50°C until the water content is less than 12%, and then crush to obtain fruit powder; Take 50g of fruit powder, add 750 mL of 80vol.% ethanol solution with a pH value of 3.0, extract with 600W ultrasonic wave at 50°C for 30min, and then centrifuge at 4000rpm for 10min. crude anthocyanin extract; then the obtained crude anthocyanin extract was purified with AB-8 macroporous resin, washed with distilled water, desorbed and eluted with 80vol.% ethanol solution, and the eluate was concentrated in vacuo at 45°C to remove ethanol, and then Vacuum freeze-drying to obtain hibiscus plum anthocyanins with an anthocyanin content of 890 mg / kg;

[0029] (2) Preparation of tremella uronic acid polysaccharide extract: Wash the discarded tremella fungus base, take 100g of ti...

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Abstract

The invention discloses a colon-targeted delivery tremella uronic acid polysaccharide-hibiscus plum anthocyanin compound and a preparation method thereof. said compound. The obtained complex has a colon-targeted release effect, which can avoid the damage of hibiscus plum anthocyanins from contacting the high acidity in the stomach, the alkaline environment of the intestinal tract and bile salts, so that the retention rate of the anthocyanins reaching the colon is above 90%, so that it can be directly Acting on colon cells, it has health effects such as mediating the structure of intestinal flora, maintaining the balance of intestinal microorganisms, and preventing and treating colon diseases.

Description

technical field [0001] The invention belongs to the technical field of food processing, and in particular relates to a colon-targeted delivery tremella uronic acid polysaccharide-hibiscus plum anthocyanin compound and a preparation method thereof. Background technique [0002] Microbes in the human gut are involved in many human physiological activities and metabolism, including food digestion, mineral absorption, regulation of immune response, they can affect body weight and digestion ability, and resist infection and autoimmune disease risk. Changes in the structure or quantity of intestinal microbial communities are closely related to human health problems such as obesity, diabetes, hypertension, and hyperlipidemia. The colon is the digestive site with the most intestinal flora, and colonic microbes are closely related to the metabolism and absorption of nutrients and functional substances in the colon. The colon-targeted delivery system can carry and release functional ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/353A23L33/125
CPCA23V2002/00A23L33/105A23L33/125A23V2200/32A23V2250/2104
Inventor 李怡彬陈君琛赖谱富吴俐汤葆莎
Owner 福建省农业科学院农产品加工研究所
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