Preparation method of tamsulosin hydrochloride sustained-release preparation
A technology for tamsulosin hydrochloride and sustained-release preparations, which can be used in pharmaceutical formulations, medical preparations without active ingredients, and medical preparations containing active ingredients, etc., and can solve problems such as changes in drug release, unfavorable oral administration, and large dosage of excipients. , to achieve the effect of stable release, good slow release function and high production efficiency
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Embodiment 1
[0023] 1) Dissolve 100 g of tamsulosin hydrochloride in 120 g of 95% ethanol to obtain tamsulosin hydrochloride ethanol solution, which is referred to as solution A;
[0024] 2) Add 120g of hydroxypropyl β-cyclodextrin and 20g of mannitol to solution A to obtain solution B;
[0025] 3) Dissolve 120g of polylactic acid and 20g of polyethylene glycol 200 in 120g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which is referred to as solution C;
[0026] 4) Mix solution B and solution C to obtain solution D;
[0027] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15°C to 18°C, continuously stir solution D for 12 hours, then reduce the temperature of solution D to 0°C to 1°C within 2 hours and let it stand for 12 hours. Hours, keep the temperature of solution D at 0°C to 1°C during the standing period;
[0028] 6) Heat the solution D obtained in step 5, and stir continuously for 12 hours when the temperature...
Embodiment 2
[0032] 1) Dissolve 100 g of tamsulosin hydrochloride in 130 g of 95% ethanol to obtain tamsulosin hydrochloride ethanol solution, which is referred to as solution A;
[0033] 2) Add 130g of hydroxypropyl β-cyclodextrin and 25g of mannitol to solution A to obtain solution B;
[0034] 3) 135g of polylactic acid and 30g of polyethylene glycol 200 were dissolved in 135g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which was designated as solution C;
[0035] 4) Mix solution B and solution C to obtain solution D;
[0036] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15°C to 18°C, continuously stir solution D for 12 hours, then reduce the temperature of solution D to 0°C to 1°C within 2 hours and let it stand for 12 hours. Hours, keep the temperature of solution D at 0°C to 1°C during the standing period;
[0037] 6) Heat the solution D obtained in step 5, and stir continuously for 12 hours when the tempe...
Embodiment 3
[0041] 1) Dissolve 100 g of tamsulosin hydrochloride in 140 g of 95% ethanol to obtain tamsulosin hydrochloride ethanol solution, which is referred to as solution A;
[0042] 2) Add 140g of hydroxypropyl β-cyclodextrin and 30g of mannitol to solution A to obtain solution B;
[0043] 3) Dissolve 150g of polylactic acid and 40g of polyethylene glycol 200 in 150g of acetone to obtain a solution of polylactic acid and polyethylene glycol 200, which is referred to as solution C;
[0044] 4) Mix solution B and solution C to obtain solution D;
[0045] 5) Transfer solution D to a magnetic stirrer, control the temperature of solution D at 15°C to 18°C, continuously stir solution D for 12 hours, then reduce the temperature of solution D to 0°C to 1°C within 2 hours and let it stand for 12 hours. Hours, keep the temperature of solution D at 0°C to 1°C during the standing period;
[0046] 6) Heat the solution D obtained in step 5, and stir continuously for 12 hours when the temperature...
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