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A kind of emulsifiable cream with anti-inflammatory, antipruritic and antibacterial effects and preparation method thereof

A technology of cream and efficacy, applied in the field of medicine, which can solve the problems of complex preparation methods, high production costs, and burning sensation on the skin, and achieve good therapeutic effect, protection of rights and interests, and less skin irritation

Active Publication Date: 2021-03-09
漳州无极药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The problem to be solved by the present invention is that the existing Wuji ointment products have a burning sensation on the skin when used, the preparation method is complicated, and the production cost is high; a kind of emulsifiable ointment with anti-inflammatory, antipruritic and antibacterial effects is provided, which is less irritating to the skin, The paste is not greasy and has the characteristics of easy cleaning

Method used

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  • A kind of emulsifiable cream with anti-inflammatory, antipruritic and antibacterial effects and preparation method thereof
  • A kind of emulsifiable cream with anti-inflammatory, antipruritic and antibacterial effects and preparation method thereof
  • A kind of emulsifiable cream with anti-inflammatory, antipruritic and antibacterial effects and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0041] 1) Take each raw material according to the dosage in Table 1;

[0042] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 80°C, and add it to the purified water previously heated to 80°C under stirring conditions to obtain the mixture A;

[0043] 3) Cool the mixture A to 58°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0044] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0045] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

[0046] Table 1 raw material consumption table (weight parts)

[0047]

[0048]

Embodiment 2

[0050] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0051] 1) Take each raw material according to the dosage in Table 1;

[0052] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 85°C, and add it to the purified water previously heated to 85°C under stirring conditions to obtain the mixture A;

[0053] 3) Cool mixture A to 55°C, add menthol, camphor, borneol, thymol, and continue stirring to obtain paste B;

[0054] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0055] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

Embodiment 3

[0057] Prepare the cream with anti-inflammatory, anti-itch and antibacterial effects, the steps are as follows:

[0058] 1) Take each raw material according to the dosage in Table 1;

[0059] 2) After mixing the emulsifier Gelot 64, stearyl alcohol and monoglyceride, heat it to 75°C, and add it to the purified water previously heated to 75°C under stirring conditions to obtain mixture A;

[0060] 3) Cool the mixture A to 56°C, add menthol, camphor, borneol, and thymol, and continue stirring to obtain paste B;

[0061] 4) Cool the paste B to 50°C, add the rest of the raw materials, stir and cool to room temperature, and the product is ready.

[0062] The prepared paste is milky white, fine and smooth in texture, and has a pH of 7.0±0.5.

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Abstract

The invention relates to a cream with anti-inflammatory, anti-itch and antibacterial effects and a preparation method thereof. The cream with anti-inflammatory, anti-itch and anti-bacterial effects comprises the following components in percentage by weight: 1.0-5.0% menthol, 5.0-5.0% camphor 10.0%, methyl salicylate 1.0-5.0%, borneol 0.5-1.0%, thymol 0.1-0.5%, beclomethasone dipropionate 0.01-0.05%, emulsifier Gelot 64 6.0-10.0%, stearyl alcohol 3.0 ~6.0%, monoglyceride 4.0~7.0% and the balance purified water. The cream of the formula of the present invention has little irritation to the skin, the paste is not greasy, has the characteristics of easy cleaning, strong stability of active components, and long storage time. The preparation method utilizes emulsifier Gelot 64, stearyl alcohol , monoglyceride and water form a homogeneous body, which simplifies the process, and also has the advantages of more stable active ingredients and a longer validity period.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a cream with anti-inflammatory, anti-itch and anti-bacterial effects and a preparation method thereof. Background technique [0002] The skin covers the surface of the human body and is the largest organ in the human body. For a long time, skin diseases have brought great troubles to people's daily production. Promise cream is the common name of compound beclomethasone camphor cream, which has anti-inflammatory, analgesic, antipruritic, antibacterial, local anesthetic effects, etc. It is effective for insect bite dermatitis, papular urticaria, eczema, contact dermatitis, neurodermatitis, skin It has a good therapeutic effect on various skin discomforts such as itching. [0003] In the prior art, there are many formulations of Wuji paste, and the preparation process is relatively complicated. Since the oil phase components and the water phase components are not well compatible, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/573A61K31/045A61K31/125A61K31/618A61K31/05A61K9/06A61K47/10A61K47/14A61P29/00A61P31/02A61P17/04A61P17/00A61P31/10
CPCA61K9/0014A61K9/06A61K31/045A61K31/05A61K31/125A61K31/573A61K31/618A61K47/10A61K47/14A61P17/00A61P17/04A61P29/00A61P31/02A61P31/10A61K2300/00
Inventor 林聪明李智祥谢建聪
Owner 漳州无极药业有限公司
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