Method of removing organic solvent from plant extract

Abstract

The invention discloses a method of removing an organic solvent from plant extract. The method comprises the following steps: S1, preparation of ginkgo biloba extract; S2, removal of ginkgolic acid bymeans of an organic solvent method; S3, removal of ginkgolic acid by means of an organic solvent-macroporous resin method; and S4, removal of phenolic acid by means of an organic solvent-macroporousresin-coordinate method. The AB-8type macroporous resin adopted by the method is relatively high in adsorption and desorption rates to flavonoid compounds and is relatively suitable for separating active components and removing phenolic acid in initial ginkgo biloba extract by adopting the organic solvent method, the macroporous resin method and the coordinate method continuously. Ginkgolic acid can form a complex with metal salt. The content of phenolic acid can be reduced effectively by adopting manganese acetate and zinc chloride. The ginkgolic acid in the initial ginkgo biloba extract is removed favorably by means of the macroporous resin method and the organic solvent method matched with the coordinate method. The ginkgo biloba extract with extremely low phenolic acid content can be obtained. The method is simple in process, convenient to operate and good in phenolic acid removal effect.

Description

technical field [0001] The invention belongs to the technical field of removing phenolic acids from ginkgo leaf extracts, and in particular relates to a method for removing organic solvents in plant extracts. Background technique [0002] Ginkgo biloba belongs to the gymnosperm phylum Ginkgoceae, which is a unique tree species in my country and has important economic value. Ginkgo biloba extract contains active ingredients such as ginkgo flavonoids and ginkgolides, which have various biological activities. Its products are widely used in medical treatment, health care products, food, cosmetics and other fields. However, Ginkgo biloba extract also contains a small amount of hemolytic, sensitizing and mutagenic ginkgolic acid compounds, and its content must be strictly controlled. The existing methods for removing ginkgolic acids in Ginkgo leaf extract mainly There are organic solvent method and macroporous resin method, although both organic solvent method and macroporous re...

AI Technical Summary

Problems solved by technology

However, Ginkgo biloba extract also contains a small amount of hemolytic, sensitizing and mutagenic ginkgolic acid compounds, and its content must be strictly controlled. The existing methods for removing ginkgolic acids in Ginkgo leaf extract mainly There are organic solvent method and macroporous resin method, although both organic solvent method and macroporous resin method can make the ginkgo leaf extract of low phenolic acid, but organic solvent method will adopt organic solvent to wash repeatedly, waste a large amount of reagents, and residual amount Large, flammable and explosive, high potential safety hazard, macroporous resin method requires special macroporous resin, expensive, complicated pretreatment, limited service life, long production cycle, and high cost