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Compound pediatric antipyretic suppository and preparation method thereof

A technology for children and antipyretics, which is applied in the field of pharmacy, can solve problems such as cavities in plugs, stratification of plugs, affecting the quality and safety of drugs, and achieve the effect of improving quality

Inactive Publication Date: 2018-12-21
JIANGXI JIUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its shortcoming is that it is mainly processed by heating, melting and mixing, and there are problems of delamination of the suppository body during the suppository molding process and bubbles and cavities in the middle of the suppository body, which seriously affects the quality and safety of the drug.

Method used

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  • Compound pediatric antipyretic suppository and preparation method thereof
  • Compound pediatric antipyretic suppository and preparation method thereof
  • Compound pediatric antipyretic suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] prescription:

[0031] Artificial bezoar 100g Acetaminophen 3kg Nanbanlan root extract powder 1kg Polysorbate 80 140g

[0032] Ethylparaben 2.1g Mixed fatty acid glyceride (type 38) 15.67kg 95% ethanol 197.93g

[0033] Preparation method:

[0034] (1) Preparation of Southern Radix Radix Radix Extract Powder Powder:

[0035] Add 1 times the amount of crude drug to the drinking water of Nanbanlangen decoction pieces, soak for 30 minutes. Decoct twice. For the first decoction, add drinking water with 5 times the amount of crude drug, and decoct for 2 hours. For the second decoction, add drinking water with 4 times the amount of crude drug, and decoct for 1.5 hours. During each extraction process, 2 forced cycles were performed, and the time of each forced cycle was 15 minutes. Combine the extracts and filter. Concentrate to a clear paste with a relative density of 1.15-1.25 (60°C), and let it cool. Transfer to an alcohol precipitation tank and add ethanol under sti...

Embodiment 2

[0047] prescription:

[0048] Artificial bezoar 100g Acetaminophen 3kg Nanbanlan root extract powder 1kg Polysorbate 80 140g

[0049] Ethylparaben 2.1g Mixed fatty acid glyceride (type 38) 15.67kg 95% ethanol 197.93g

[0050] Preparation method:

[0051] (1) Preparation of Southern Radix Radix Radix Extract Powder Powder:

[0052]Add 1 times the amount of crude drug to the drinking water of Nanbanlangen decoction pieces, soak for 30 minutes. Decoct twice. For the first decoction, add drinking water with 5 times the amount of crude drug, and decoct for 2 hours. For the second decoction, add drinking water with 4 times the amount of crude drug, and decoct for 1.5 hours. During each extraction process, 2 forced cycles were performed, and the time of each forced cycle was 15 minutes. Combine the extracts and filter. Concentrate to a clear paste with a relative density of 1.15-1.25 (60°C), and let it cool. Transfer to an alcohol precipitation tank and add ethanol under stir...

Embodiment 3

[0062] prescription:

[0063] Artificial bezoar 100g Acetaminophen 3kg Nanbanlan root extract powder 1kg Polysorbate 80 140g

[0064] Ethylparaben 2.1g Mixed fatty acid glyceride (type 38) 15.67kg 95% ethanol 197.93g

[0065] Preparation method:

[0066] (1) Preparation of Southern Radix Radix Dry Paste Powder:

[0067] Add 1 times the amount of crude drug to the drinking water of Nanbanlangen decoction pieces, soak for 30 minutes. Decoct twice. For the first decoction, add drinking water with 5 times the amount of crude drug, and decoct for 2 hours. For the second decoction, add drinking water with 4 times the amount of crude drug, and decoct for 1.5 hours. During each extraction process, 2 forced cycles were performed, and the time of each forced cycle was 15 minutes. Combine the extracts and filter. Concentrate to a clear paste with a relative density of 1.15-1.25 (60°C), and let it cool. Transfer to an alcohol precipitation tank and add ethanol under stirring to ma...

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Abstract

The invention discloses a compound pediatric antipyretic suppository and a preparation method thereof. An ultra-fine pulverization technology and a grinding technology are combined to be applied to the preparation method of the compound pediatric antipyretic suppository, so that raw materials of the compound pediatric antipyretic suppository can be pulverized sufficiently, a liquid of the compoundpediatric antipyretic suppository is ground thoroughly and uniformly, the problems of suppository layering and bubbles in the middle of the suppository in a suppository forming process are solved, and quality of the compound pediatric antipyretic suppository is improved. The preparation process is convenient and practical, and product quality is easy to control.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a compound children's antipyretic suppository and a preparation method thereof. Background technique [0002] Compound Xiaoer Tuire Suppository is a torpedo-shaped suppository with a grain weight of 1.0 g, which is made by adding artificial bezoar, Nanbanlangen extract powder, and acetaminophen into mixed fatty acid glyceride (type 38). The mode of administration is rectal administration. It has the effects of antipyretic and analgesic, relieving sore throat and detoxification, eliminating phlegm and relieving convulsion. It is used to treat children with fever, palpitations, sore throat and cough due to lung heat and phlegm. [0003] The existing preparation method of compound Xiaoer antipyretic suppository: artificial bezoar, Nanbanlangen dry cream powder, and acetaminophen three flavors are added in small amounts to semi-synthetic fatty acid glycerides kept at about 50°C,...

Claims

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Application Information

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IPC IPC(8): A61K9/02A61K47/26A61K47/14A61K36/195A61P29/00A61K35/413A61K31/167
CPCA61K9/02A61K31/167A61K35/413A61K36/195A61K47/14A61K47/26A61P29/00A61K2300/00
Inventor 宋九红许焰辉雷迅
Owner JIANGXI JIUHUA PHARMA