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Application of ginkgo biflavonoid compound in preparation of slimming medicines and/or sliming medicine compositions

A technology of ginkgo biflavonoids and compounds, which is applied in the field of biomedicine, can solve problems such as the lack of systematic research on the inhibitory effect of pancreatic lipase, and achieve the effects of good application prospects, high yield and easy availability of raw materials

Inactive Publication Date: 2018-12-21
大连天星本草生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, although the reported effects of ginkgobioflavones are many, the inhibitory effect of this type of ingredient on pancreatic lipase has not been systematically studied, nor has there been any report on the use of this type of ingredient to treat hyperlipidemia and obesity

Method used

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  • Application of ginkgo biflavonoid compound in preparation of slimming medicines and/or sliming medicine compositions
  • Application of ginkgo biflavonoid compound in preparation of slimming medicines and/or sliming medicine compositions
  • Application of ginkgo biflavonoid compound in preparation of slimming medicines and/or sliming medicine compositions

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] The present embodiment prepares ginkgo double flavonoid tablet

[0046] Accurately weigh 10 g of ginkgo biflavone components (the purity of ginkgo biflavanoids is greater than 98%), add 190 g of medicinal starch, and mix the two thoroughly to make 400 tablets, each weighing 0.5 g, containing 25 mg of ginkgo biflavones.

Embodiment 2

[0048] The present embodiment prepares isoflavone tablet of different ginkgo biloba

[0049] Accurately weigh 10 g of isoflavone components (the purity of isoflavones is greater than 98%), add 190 g of medicinal starch, and mix the two thoroughly to make 400 tablets, each weighing 0.5 g, containing 25 mg of isoflavones.

Embodiment 3

[0051] The present embodiment prepares ginkgo biflavone capsules

[0052] Accurately weigh 10g of ginkgo biflavone components (purity greater than 98%), add 190g of medicinal starch, mix the two fully and use a 20-mesh sieve to make granules, then subpackage and fill them into hollow capsules, and subpackage into 400 capsules , each capsule weighs 0.5g, containing 25mg of ginkgo biflavone.

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Abstract

The invention provides application of a ginkgo biflavonoid compound in the preparation of slimming medicines and / or sliming medicine compositions. The ginkgo biflavonoid compound has the advantages that the activity of pancreatic lipase can be effectively inhibited, and the IC50 of inhibited pancreatic lipase is 2.90mum to 12.78mum; especially, the oral dose of the ginkgo biflavonoid is 4.5 to 12.5mg, the local exposure amount in the gastrointestinal system can reach 2.27 to 7.67mum, and the inhibiting constant is higher than the inhibiting constant (Ki=0.81mum) of the ginkgo biflavonoid on the pancreatic lipase, which indicates that the in-vitro medicine exposure concentration of the ginkgo biflavonoid can inhibit the pancreatic lipase at high efficiency, and further improve the digestionand absorption of lipid in the human body; the raw materials are easy to obtain, the safety is high, the extracting and preparation technologies are simple, the yield rate is high, and the like; a novel medicine source is provided for the preventing and controlling on the fat, and the good application prospect is realized in the preparation of the slimming medicines.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of ginkgo biflavonoids in the preparation of weight-loss drugs and / or weight-loss drug compositions. Background technique [0002] Due to modern lifestyles and the intake of high-fat and high-sugar diets, the incidence of obesity and overweight patients has risen sharply, which has attracted widespread attention. Obesity and overweight have been closely associated with elevated blood glucose and lipid levels, and are important risk factors for the development of various metabolic diseases, such as hyperlipidemia, hypertension, arteriosclerosis, non-insulin-dependent diabetes mellitus, coronary heart disease, and certain types of cancer. Therefore, it is very necessary to discover and prepare drugs for reducing blood fat and weight loss, and one of the strategies for preventing obesity is to reduce the digestion and absorption of fat in the digestive system. Pancreatic l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P3/04
CPCA61K31/352A61P3/04
Inventor 侯洁刘磊葛广波侯旭东
Owner 大连天星本草生物科技有限公司
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