Animal brucellosis gel adjuvant pre-filling vaccine and preparation method thereof

Abstract

The invention discloses an animal brucellosis gel adjuvant pre-filling vaccine and a preparation method thereof, and relates to the field of animal immunization. The preparation method of the animal brucellosis gel adjuvant pre-filling vaccine comprises the following steps: preparing a gel adjuvant; preparing a brucellosis gel vaccine, and mixing Brucella liquid with the gel adjuvant to obtain 1mLof gel vaccine containing one-animal vaccine amount; sub-packaging the gel vaccine in dosing tubes, 1-1.2mL for each dosing tube; performing first disinfection and second disinfection of the exteriorof the dosing tubes containing the gel vaccine; packaging the gel vaccine and performing third disinfection. During implementation of the invention, only the sub-packaging people in a laboratory directly touch the vaccine, and the immunization operators indirectly touch the vaccine, thus the contact between the operators and the vaccine is minimized, middle steps are reduced, and the infection risk is lowered by 80% or more.

Description

technical field [0001] The application relates to the field of animal immunization, in particular to an animal brucellosis gel adjuvant prefilled vaccine and a preparation method thereof. Background technique [0002] In recent years, brucellosis among livestock has resurged, and most parts of the country are Class I epidemic areas, so it is necessary to immunize livestock. Because the Brucella vaccine is a live virus, repeated exposure to the vaccine can cause infection in humans. At present, in the prevention and control of Brucella, the operator needs to wear protective equipment above the European standard biosafety level 3 protection, and then dilute the vaccine with a fully sealed internal circulation dispenser, and then administer the Brucellosis vaccine to cattle and sheep immunity. According to the immunization requirements, every time an animal is immunized, the dosing tube needs to be replaced or the dosing tube must be wiped and disinfected to achieve one anima...

AI Technical Summary

Problems solved by technology

[0004] On the one hand, due to the high cost of protection, some operators do not have the funds to purchase protective equipment, resulting in infection

On the other hand, aerosols are generated when the vaccine is diluted, and repeated exposure to the vaccine can cause infection to the operator

On the other hand, due to the bad habits of the operators during the operation, such as incomplete disinfection of special instruments after immunization, etc., infection

It is reported that the infection rate of operators exceeds 25%, which has created a great psychological shadow on the professionals, forming panic, and causing them not to be immune

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