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Shape memory composite bone nail and preparation, using method and application thereof

A bone nail and memory technology, applied in the field of shape memory composite bone nails, can solve the problems of inconsistent biocompatibility and material strength, poor shape memory performance, etc.

Active Publication Date: 2018-12-25
THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problems existing in the existing bone repair bone nails that the biocompatibility and material strength cannot be coordinated and unified, and the shape memory performance is not good, the present invention provides a shape memory composite bone nail

Method used

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  • Shape memory composite bone nail and preparation, using method and application thereof
  • Shape memory composite bone nail and preparation, using method and application thereof

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preparation example Construction

[0050] In one embodiment, the preparation method at least includes the following steps:

[0051] Weigh hydroxyapatite, RGD tripeptide, diphenylmethane diisocyanate, chain extender and polycaprolactone diol according to the above-mentioned raw material ratio;

[0052] The diphenylmethane diisocyanate and polycaprolactone diol are mixed for the first time, then the hydroxyapatite is added for ultrasonic dispersion, and the chain extender is added for the second mixing deal with;

[0053] placing the material obtained through the second mixing process in a bone nail mold for pouring and molding treatment to obtain a hydroxyapatite / polyurethane shape memory composite bone nail;

[0054] placing the hydroxyapatite / polyurethane shape memory composite bone nail in the MES buffer solution containing the RGD tripeptide for soaking at room temperature;

[0055] Drying the soaked bone nail to obtain a shape-memory composite bone nail.

[0056] The above-mentioned preparation method is...

Embodiment 1

[0074] A method for preparing a shape-memory composite bone nail, comprising the following steps:

[0075] 1) According to the following raw material components in mass percentage:

[0076] Hydroxyapatite 2.0%;

[0077] RGD tripeptide 1.0%;

[0078] Polyurethane 97.0%;

[0079] Wherein, based on 100% of the polyurethane mass, the following raw material components are reacted:

[0080] Diphenylmethane diisocyanate 60.0%;

[0081] Chain extender 15.0%;

[0082] Polycaprolactone diol 25.0%.

[0083] Weigh 20 g of hydroxyapatite, 10 g of RGD tripeptide, 600 g of diphenylmethane diisocyanate, 150 g of 1,4-butanediol, and 250 g of polycaprolactone diol.

[0084] 2) Mix 600 g of diphenylmethane diisocyanate and 250 g of polycaprolactone diol at a stirring speed of 800 rpm / min at 85° C. and stir for 2 hours to obtain the first material.

[0085] 3) The second material was mixed with 20 g of hydroxyapatite, and ultrasonically dispersed for 1 hour under ultrasonic conditions of 3...

Embodiment 2

[0090] A method for preparing a shape-memory composite bone nail, comprising the following steps:

[0091] 1) According to the following raw material components in mass percentage:

[0092] Hydroxyapatite 2.0%;

[0093] RGD tripeptide 0.5%;

[0094] Polyurethane 97.5%;

[0095] Wherein, based on 100% of the polyurethane mass, the following raw material components are reacted:

[0096] Diphenylmethane diisocyanate 55.5%;

[0097] Chain extender 16.0%;

[0098] Polycaprolactone diol 28.5%.

[0099] Weigh 20 g of hydroxyapatite, 5 g of RGD tripeptide, 550 g of diphenylmethane diisocyanate, 160 g of 1,4-butanediol, and 285 g of polycaprolactone diol.

[0100] 2) Mix 550 g of diphenylmethane diisocyanate and 285 g of polycaprolactone diol at a stirring speed of 800 rpm / min at 85° C. and stir for 2 hours to obtain the first material.

[0101] 3) The second material was mixed with 20 g of hydroxyapatite, and ultrasonically dispersed for 1 hour under ultrasonic conditions of 30...

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Abstract

The invention relates to the technical field of bone tissue repair, and particularly discloses a shape memory composite bone nail and preparation, a using method and application thereof. The shape memory composite bone nail comprises the following raw material components in percentages by mass: 1.8-2.2% of hydroxyapatite, 0.5-1.5% of RGD tripeptide and 96.5-97.5% of polyurethane. The polyurethaneis prepared from the following raw material components by reaction based on 100% of the polyurethane by mass: 55.0-57.0% of diphenylmethane diisocyanate, 14.0-16.0% of a chain extender and 28.0-30.0%of polycaprolactone glycol. The shape memory composite bone nail has a shape memory function, a self-regulated mechanical property and a tissue growth function; the hydroxyapatite does not affect theshape memory function, but also has good biological compatibility and histocompatibility, and is suitable for the field of repair of bone tissues.

Description

technical field [0001] The invention relates to the technical field of bone tissue repair, in particular to a shape-memory composite bone nail and its preparation, use and application. Background technique [0002] As one of the important means of internal fixation of bone defects caused by fractures and osteoporosis, bone nails have always been given a lot of attention. [0003] When bone defect occurs, the reduction of bone quality directly affects the stability of fixation and the holding force of screws. According to the characteristics of bone defects, traditional internal fixation materials are generally made of stainless steel, titanium and their alloys. However, when implanted in the human body for a long time, internal fixation materials made of stainless steel, titanium and their alloys will cause corrosion, allergies, Osteoporosis was caused by stress shielding, and fractures occurred again after surgery, and most of them needed to be taken out again. [0004] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/00A61L31/02A61L31/14C08G18/42
CPCA61L31/00A61L31/028A61L31/06A61L31/14A61L2400/16A61L2400/18C08G18/4277C08L75/04
Inventor 胡金莲张原驰
Owner THE HONG KONG POLYTECHNIC UNIV SHENZHEN RES INST
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