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Application of astragalin in preparation of drug for treating diabetic testicular dysfunction

A technology of astragaloside and diabetes, which is applied in the field of astragaloside in the field of preparing a drug for treating diabetic testicular dysfunction, and achieves the effects of improving testicular tissue changes and reducing spermatogenesis.

Active Publication Date: 2018-12-28
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, studies at home and abroad have found that astragalin also has various pharmacological activities and clinical functions such as anti-inflammation and anti-oxidation, but there is no information about its protective effect on diabetic testicular function damage, especially spermatogenesis damage. Literature report

Method used

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  • Application of astragalin in preparation of drug for treating diabetic testicular dysfunction
  • Application of astragalin in preparation of drug for treating diabetic testicular dysfunction
  • Application of astragalin in preparation of drug for treating diabetic testicular dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The use of ascarin in the preparation of medicines for treating diabetic testicular dysfunction, wherein the diabetic testicular dysfunction is diabetic spermatogenesis damage, and the single application dose of ascarin is 3.3mg / kg for mice, and the medicine The dosage form is oral dosage form.

Embodiment 2

[0035] The use of astragalin in the preparation of medicines for treating diabetic testicular dysfunction, wherein the diabetic testicular dysfunction is diabetic spermatogenesis impairment, and the single application dose of ascarin is 10 mg / kg for mice. The dosage form is an oral dosage form.

Embodiment 3

[0037] The use of astragalin in the preparation of medicines for treating diabetic testicular dysfunction, wherein the diabetic testicular dysfunction is diabetic spermatogenesis impairment, the single application dose of astragalin is 30 mg / kg for mice, and the dose of the drug is The dosage form is an oral dosage form.

[0038] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0039] 1. Experimental materials

[0040] 1.1 Animal handling

[0041] SPF-grade ICR male adult mice weighing between 23-27 g were bred by the Experimental Animal Center of Ningxia Medical University (animal incubation batch number: SCXK (Ning) 2017-0001). Animals were fed according to the experimental animal feeding standards, and the feeding room was artificially controlled to alternate day and night for 12 hours, and the mice drank water freely.

[0042] 1.2 Experimental drugs and instruments

[0043] The main drugs and reagents that will ...

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Abstract

The invention discloses application of astragalin in preparation of a drug for treating diabetic testicular dysfunction. An experimental result shows that when the astragalin is used in a safety doserange, the dose is 30 mg / kg of astragalin, the astragalin can remarkably protect sperm injury induced by a diabetes model, improve pathologic change of testicular tissue, improve the oxidation resistance ability and regulate and control protein expression of inflammatory cytokines, and it is proved that the astragalin has the effect of improving the diabetic testicular dysfunction.

Description

technical field [0001] The present invention relates to the application of ascarin, in particular to the use of ascarin in the preparation of medicines for treating diabetic testicular function impairment. Background technique [0002] Diabetes mellitus (DM) is a metabolic disease caused by multiple etiologies and characterized by hyperglycemia. In recent years, studies have found that patients with long-term diabetes will have severe complications and even lead to organ dysfunction and failure with the occurrence of hyperglycemia. With the deepening of research, male reproductive damage caused by diabetes has received great attention. At present, the clinical manifestations of diabetic male reproductive function impairment are sexual dysfunction, low fertility, and impairment of spermatogenic function. A series of problems such as insufficient enzyme secretion are a hot spot and focus of research on diabetic male reproductive damage. Clinically, most of the drugs used to...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P3/10A61P15/00
CPCA61K31/7048A61P3/10A61P15/00
Inventor 余建强韩晓旭刘宁郑萍李玉香
Owner NINGXIA MEDICAL UNIV
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