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A kind of silk fibroin light-cured hydrogel and preparation method thereof

A silk fibroin, light curing technology, applied in the field of hydrogel materials, can solve the problems of cytocompatibility and other issues

Active Publication Date: 2021-04-09
NANTONG TEXTILE & SILK IND TECH RES INST +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the prepared silk fibroin hydrogel material may have certain cytotoxicity due to the addition of hydrogen peroxide, which has a certain impact on the study of cytocompatibility.

Method used

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  • A kind of silk fibroin light-cured hydrogel and preparation method thereof

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Experimental program
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Effect test

Embodiment 1

[0023] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO 3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent ...

Embodiment 2

[0031] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO 3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent ...

Embodiment 3

[0038] (1) Preparation of silk fibroin aqueous solution: weigh 3g of anhydrous NaHCO 3 and 1 g anhydrous Na 2 CO 3 Put into boiling 4L deionized water, add 80g silkworm cocoon after fully dissolving, adjust the solution state to slightly boil, stir once every 10 minutes with a glass rod, wash it with deionized water after 30 minutes, repeat the above operation 3 times, each time Weigh new anhydrous NaHCO 3 and anhydrous Na 2 CO 3 ; After fully washing, loosen the silk and put it in a 60°C oven for drying. Take 100ml of 9.3mol / L lithium bromide solution and pour it into a conical flask, heat it to 65°C in a constant temperature magnetic stirrer, add 15g of degummed silk fibroin in several times, and dissolve it at 65±2°C for 30~ After cooling for 40 minutes, take it out, put it in a dialysis bag and seal it, place it in deionized water at low temperature for dialysis for 3 to 4 days, after the dialysis is completed, filter the obtained silk fibroin solution with absorbent ...

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Abstract

The invention relates to a silk fibroin light-cured hydrogel and a preparation method thereof. It uses silk fibroin as raw material, and prepares silk fibroin hydrogel with interpenetrating network structure through ultraviolet light curing. The monomer N-vinylpyrrolidone is dissolved in the silk fibroin solution, and N-vinylpyrrolidone is catalyzed and polymerized by ultraviolet light and horseradish peroxidase to form polyvinylpyrrolidone macromolecules and silk fibroin molecular chains to physically entangle, A new silk fibroin hydrogel with good light transmittance and excellent degradation performance was obtained.

Description

technical field [0001] The invention relates to the technical field of hydrogel materials, in particular to a novel silk fibroin hydrogel cured by ultraviolet light and a preparation method thereof. Background technique [0002] Silk is a continuous long fiber formed by the cocooning of silkworms secreted by silkworms when they cocoon. Silk fibroin is a natural polymer protein derived from silk. Its content accounts for 70% to 80% of silk. It contains 18 kinds of amino acids, 11 of which are essential amino acids for human body. On the other hand, silk fibroin is non-toxic to human body. Function, safe and reliable, with good biocompatibility, suitable for development into functional materials. Therefore, with the in-depth research on its unique amino acid composition and crystal structure and other physical and chemical properties, the application of silk fibroin at home and abroad is actively exploring from the traditional textile field to many fields, and the application...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08J3/28C08L89/00
CPCC08J3/075C08J3/28C08J2389/00
Inventor 卢神州姜福建吴峰匡大江
Owner NANTONG TEXTILE & SILK IND TECH RES INST