Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Tissue engineering meniscus composite scaffold and preparation method thereof

A composite scaffold and tissue engineering technology, applied in the field of medical devices, can solve problems such as aggravating knee osteoarthritis, accelerating degenerative joint changes, and changing the microenvironment of the knee joint, to protect the knee joint, promote regeneration and repair, and achieve excellent mechanical properties. and biocompatibility

Active Publication Date: 2019-01-15
GENERAL HOSPITAL OF PLA
View PDF14 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current tissue engineering scaffolds are difficult to take into account the excellent mechanical properties and biocompatibility at the same time, and there are still many deficiencies in the shape, structure, mechanical properties and physiological functions of the formed new meniscus, which may even cause changes in the microenvironment of the knee joint. Accelerates degenerative joint changes or exacerbates knee osteoarthritis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Tissue engineering meniscus composite scaffold and preparation method thereof
  • Tissue engineering meniscus composite scaffold and preparation method thereof
  • Tissue engineering meniscus composite scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0049] The preparation method of the tissue engineered meniscus composite support of one embodiment of the present invention comprises the following steps:

[0050] Modeling step S100, constructing a three-dimensional data model of the undamaged meniscus to be regenerated and repaired.

[0051] As an example, step S100 includes:

[0052] Step S110, obtaining medical image data of the intact meniscus corresponding to the meniscus to be regenerated and repaired by micro computed tomography (micro computed tomography, Micro-CT for short) or magnetic resonance imaging (Magnetic Resonance Imaging, MRI for short) .

[0053] The intact meniscus corresponding to the meniscus to be regenerated and repaired may be the meniscus corresponding to the meniscus to be regenerated and repaired in the patient's intact knee joint.

[0054] According to the precise medical imaging data of the meniscus of the individual, a composite meniscus bracket that precisely matches the individual can be p...

Embodiment 1

[0088] Through Micro-CT imaging technology, the medical image data of the medial meniscus of Mianyang was obtained, and three-dimensional reconstruction was performed to obtain the three-dimensional data model of the medial meniscus of sheep;

[0089] preparing the extracellular matrix of the decellularized meniscus by physical decellularization, and preparing an aqueous solution containing the extracellular matrix of the decellularized meniscus, wherein the volume ratio of the mass of the extracellular matrix of the decellularized meniscus to the aqueous solution is 2%;

[0090] Polycaprolactone is used as raw material to print the scaffold according to the three-dimensional data model, which is C-shaped and consistent with the initial shape of the meniscus to be regenerated and repaired. The scaffold includes a plurality of first degradable high Molecular material fibers and a plurality of second degradable polymer material fibers extending radially along the scaffold, the fi...

Embodiment 2

[0094] The difference from Example 1 is that the degradable polymer material is polylactic acid-glycolic acid copolymer, and the matrix material is type I collagen, which is cross-linked by irradiation.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
diameteraaaaaaaaaa
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention discloses a tissue engineering meniscus composite scaffold and a preparation method thereof. The scaffold comprises: a C-shape bracket which is consistent with the initial shape of meniscus to be regenerated and repaired, the bracket comprising a plurality of first degradable polymer material fibers extending in a circumferential direction of the bracket and a plurality of second degradable polymer material fibers extending in a radial direction of the bracket, the first degradable polymer material fiber and the second degradable polymer material fiber being arranged in a multilayer cross arrangement to form a frame structure having a plurality of first pores; a matrix material composited within a plurality of first apertures of the stent to form a meniscus composite stent having a plurality of second apertures. The meniscus composite scaffold provided by the invention has excellent mechanical properties and biocompatibility, and can provide an excellent microenvironmentrequired for cell growth, thereby enabling the newborn meniscus to have excellent shape, structure, mechanical properties and physiological functions.

Description

technical field [0001] The application belongs to the technical field of medical devices, and in particular relates to a tissue engineering meniscus composite bracket and a preparation method thereof. Background technique [0002] The meniscus is located between the femoral condyle and the tibial plateau, one inside and one inside. Its main function is to nourish the knee joint, lubricate the knee joint, stabilize the knee joint and buffer the stress of the knee joint. The damage and degeneration of the meniscus will cause the loss of meniscus function, reduce the protective effect on knee cartilage, and induce knee joint diseases. Clinically, partial or total meniscus resection can be performed to solve the problem of meniscus damage and degeneration, and to relieve knee joint symptoms in the short term. However, if the meniscus injury and degeneration occur in the inner part of the avascular area, it is often difficult to heal itself after resection, which will inevitably...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/38A61L27/56A61L27/50
CPCA61F2/30942A61F2/3872A61L27/50A61L27/56A61L2430/06A61F2/30756A61F2/30771A61F2002/30062A61F2002/30131A61F2002/30766A61F2002/3092A61F2002/30985A61L27/48A61L27/58A61L27/26A61L27/3633A61L27/3654B33Y10/00B33Y70/00B33Y80/00B33Y50/02B29C64/106B33Y40/20B33Y70/10C08L67/04A61F2002/30784A61F2002/30952
Inventor 郭全义郭维民卢世璧刘舒云眭翔黄靖香陈明学王振勇高爽苑志国
Owner GENERAL HOSPITAL OF PLA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com