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A bendazac lysine eye drop, and a preparation method thereof and application

A technology of benzyl lysine and eye drops, applied in the field of medicine, can solve the problems of poor patient compliance, increased secretion, redness and swelling in the patient's eyes, etc., and achieves the effects of improving compliance, alleviating injury and irritation

Inactive Publication Date: 2019-01-15
湖北远大天天明制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the relevant literature and adverse reaction tests of the drug have reported that benzalaxine is highly irritating to the eyes, which can easily lead to redness and swelling and increased secretions in the eyes of patients, and the incidence of adverse reactions in clinical use increases, which can easily lead to poor patient compliance

Method used

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  • A bendazac lysine eye drop, and a preparation method thereof and application
  • A bendazac lysine eye drop, and a preparation method thereof and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment one, the eye drops of benzyl-lysine

[0022] An ophthalmic solution of Bendazyl-lysine containing a cooling agent is characterized in that it contains an active ingredient, an auxiliary material and a solvent, wherein the active ingredient is composed of Bendazyl-lysine and a cooling agent. Wherein, the content of the active ingredients is 0.4-0.5% of benzyl lysine and 0.5-1.3% of the cooling agent in terms of mass percentage. The content of the auxiliary materials is 1.0-3.0% of the pH regulator sodium dihydrogen phosphate and / or disodium hydrogen phosphate, 0.5-2.0% of the osmotic pressure regulator sodium chloride, and 0.1-0.3% of the solubilizer hypromellose , indicating that the active agent polysorbate is 0.2-0.5%, and the preservative benzalkonium chloride is 0.01-0.03%. The solvent is water for injection, or other oily solvents or water-containing emulsions can be used according to the situation. The cooling agent is borneol, menthol or camphor or a...

Embodiment 2

[0025] Embodiment two, the preparation method of the eye drops of benzyl-lysine

[0026] It mainly includes the following four steps:

[0027] Step 1, dissolving the prescribed amount of solubilizing agent in part of the solvent under heating conditions;

[0028] Step 2, adding the pH regulator and osmotic pressure regulator of the prescribed amount into a solution and then adding it to the liquid obtained in step 1;

[0029] In step 3, the benzyl lysine, surfactant and cooling agent of the prescribed amount are prepared into a liquid and then added to the liquid obtained in step 2;

[0030] Step 4: Add the prescribed amount of preservative to the liquid obtained in Step 3, heat the liquid medicine, cool the liquid medicine until it is clear, and add a solvent to make it volume.

[0031] As an optimization, the temperature of the heating condition in step 1 is above 90° C., and part of the solvent refers to 75% of the recipe amount.

[0032] For further optimization, the he...

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Abstract

The invention provides a bendazac lysine eye drop, and a preparation method thereof and application, comprising an active ingredient, an auxiliary material and a solvent, wherein the active ingredientis composed of bendazac lysine and a refreshing agent and particularly includes 0.4-0.5% of the bendazac lysine and is 0.5-1.3 of the refreshing agent by mass; the auxiliary material includes, by mass, 1.0-3.0% of sodium dihydrogen phosphate and / or disodium hydrogen phosphate as pH regulator, 0.5-2.0% of an osmotic pressure regulator sodium chloride, 0.1-0.3% of solubilizer hydroxypropyl methylcellulose, 0.2-0.5% of a surfactant polysorbate and 0.01-0.03% of a preservative benzalkonium chloride. As that refreshing agent is added, the cornea and the nerve can be cool when in contact with the eye, thereby alleviating the injury and irritation to the cornea of the bendazac lysine and other adjuvants, and improving the compliance of the patient in use.

Description

technical field [0001] The invention relates to an eye drop, which belongs to the field of medicine. Background technique [0002] Bendalysine is an aldose reduction inhibitor. Aldose reductase can promote the reduction of glucose and galactose in the human lens into alcohols that are difficult to penetrate into the cell membrane, and absorb water outside the cell membrane into the lens, causing the lens protein fibers to swell and disrupt the structure. , Changing the light transmission to form cataracts. Bendalysine eye drops can enter the eye tissue and aqueous humor through local eye drops, and concentrate in the lens, effectively inhibit the activity of aldose reductase in the eye, delay the development of cataract, and achieve the prevention or treatment of cataract the goal of. [0003] The formula of Bendax lysine eye drops usually contains Bendax lysine, sodium dihydrogen phosphate, disodium hydrogen phosphate, sodium chloride, hypromellose, polysorbate 80, benzal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K47/10A61K31/416A61P27/12
CPCA61K9/0048A61K9/08A61K31/416A61K47/10A61P27/12
Inventor 尹传忠付欢万利鹏延静王超陈璐
Owner 湖北远大天天明制药有限公司