Droplet splitting microfluidic chip and its application
A microfluidic chip and microfluidic device technology, applied in the field of microfluidics, can solve the problems of difficult to obtain flow field stability of the pump valve system, expensive equipment processing, difficult to achieve precise control, etc., to shorten the production time , simplified structure and low reagent consumption
Active Publication Date: 2021-01-05
SHENZHEN INST OF ADVANCED TECH
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Problems solved by technology
However, in the above systems, the processing of instruments and equipment is expensive, and the pump and valve system is difficult to obtain flow field stability and precise control
And the use of an external electric field or temperature field has a certain destructive effect on the droplet.
Method used
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[0036] The following descriptions are preferred implementations of the embodiments of the present invention. It should be pointed out that those skilled in the art can make some improvements and modifications without departing from the principles of the embodiments of the present invention. These improvements And retouching are also regarded as the scope of protection of the embodiments of the present invention.
[0037] The terms "comprising" and "having" and any variations thereof appearing in the specification, claims and drawings of this application are intended to cover non-exclusive inclusion. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but optionally also includes unlisted steps or units, or optionally further includes For other steps or units inherent in these processes, methods, products or apparatuses. Terms such as "first" and "second" in this application are only used ...
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Abstract
Embodiments of the present invention provide a droplet splitting microfluidic chip. The chip comprises a substrate. The substrate comprises at least one splitting unit. The splitting unit comprises adroplet storage chamber, and M microchannels and converge assemblies communicated with the droplet storage chamber, wherein M is greater than or equal to 2. A mother droplet inflow inlet is arranged in the droplet storage chamber. The diameter of the mother droplet inflow inlet is greater than that of the microchannel. The converging assembly comprises one droplet outflow channel. After the motherdroplet enters the droplet storage chamber from the mother droplet inflow inlet, the mother droplet is split into sub-droplets through the M microchannels. The sub-droplets are converged into the onedroplet outflow channel through the converge assemblies and then are discharged. The droplet splitting microfluidic chip realize rapid and high-flux splitting of droplets and has the characteristicsof strong initiative, high flexibility and mild operating conditions. The invention also provides a use of the droplet splitting microfluidic chip.
Description
technical field [0001] The invention relates to the field of microfluidic technology, in particular to a droplet splitting microfluidic chip and its application. Background technique [0002] As an important branch of microfluidic chip research, droplet microfluidics has been developed on the basis of traditional continuous flow microfluidic systems in recent years, using two immiscible (such as water and oil) or multiple The discontinuous flow microfluidic technology that produces dispersed micro-droplets in the liquid phase for experimental manipulation. With the rapid development of modern high-tech science and technology, micro-droplets in droplet microfluidic technology have been widely used in medicine, biology, power, chemical industry, nuclear energy, petroleum, Metallurgy and other fields. The size, stability, and uniformity of micro-droplet formation all seriously affect its application effect. [0003] Droplet microfluidic technology mainly includes droplet gen...
Claims
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IPC IPC(8): B01L3/00
CPCB01L3/502707
Inventor 张宝月陈艳
Owner SHENZHEN INST OF ADVANCED TECH