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Toadstool and bolete compound crude polysaccharide as well as preparation method and medical application thereof

A technology of boletus and hickory chick, which is applied in the direction of polysaccharide/gum-containing food ingredients, medical preparations containing active ingredients, applications, etc., to achieve significant health benefits and good market development prospects

Active Publication Date: 2019-02-15
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] After searching, there is no literature report that the two have medical effects on alcoholic liver disease

Method used

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  • Toadstool and bolete compound crude polysaccharide as well as preparation method and medical application thereof
  • Toadstool and bolete compound crude polysaccharide as well as preparation method and medical application thereof
  • Toadstool and bolete compound crude polysaccharide as well as preparation method and medical application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Take 100g of Morchella sporocarp, pulverize it with a high-speed pulverizer, and pass through a 100-mesh sieve to prepare the Morchella sporocarp powder, then add 15 times of deionized water, extract twice at 80°C, and combine the extracts to obtain the Morchella sporocarp powder. Aqueous extract of belly mushroom. Get boletus fruiting body 100g, prepare boletus aqueous extract according to the above-mentioned same method. Take the above-mentioned morel water extract and boletus water extract and mix them at a volume ratio of 1:1, and mix them at 50 r / min at 4°C for 24 hours to allow them to fully interact. Then, concentrate under reduced pressure to 60 mL, add 95% ethanol at a volume ratio: 1:3, let stand overnight at room temperature, then centrifuge at 3500 r / min for 10 min, collect the precipitate, and freeze-dry at -50°C for 72 hours. The morel and boletus compound crude polysaccharide freeze-dried powder was obtained.

[0017] Remarks: The preparation methods of...

Embodiment 2

[0020] Take 100g of Morchella sporocarp, pulverize it with a high-speed pulverizer, and pass through a 100-mesh sieve to prepare the Morchella sporocarp powder, then add 20 times of deionized water, extract twice at 90°C, and combine the extracts to obtain the Morchella sporocarp powder. Aqueous extract of belly mushroom. Get boletus fruiting body 100g, prepare boletus aqueous extract according to the above-mentioned same method. The above-mentioned morel water extract and boletus water extract were mixed according to the volume ratio of 2:1, and mixed at 60 r / min at 4°C for 36 hours to allow them to fully interact. Then, concentrate under reduced pressure to 50 mL, add 95% ethanol at a volume ratio of 1:4, let stand at room temperature overnight, then centrifuge at 3000 r / min for 10 min, collect the precipitate, and freeze-dry at -40°C for 80 hours. The morel and boletus compound crude polysaccharide freeze-dried powder was obtained.

[0021] Remarks: The preparation method...

Embodiment 3

[0024] Take 100g of Morchella sporocarp, pulverize it with a high-speed pulverizer, and pass through a 100-mesh sieve to prepare the Morchella sporocarp powder, then add 30 times of deionized water, extract twice at 100°C, and combine the extracts to obtain the Morchella sporocarp powder. Aqueous extract of belly mushroom. Get boletus fruiting body 100g, prepare boletus aqueous extract according to the above-mentioned same method. The above-mentioned morel water extract and boletus water extract were mixed according to the volume ratio of 3:1, and mixed at 70 r / min at 4°C for 48 hours to allow them to fully interact. Subsequently, it was concentrated under reduced pressure to 75 mL, and 95% ethanol was added according to the volume ratio: 1:5, left standing overnight at room temperature, and then centrifuged at 4000 r / min for 10 min, the precipitate was collected, and lyophilized at -30°C for 65 hours to obtain Morel and boletus compound crude polysaccharide freeze-dried powd...

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PUM

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Abstract

The invention provides a toadstool and bolete compound crude polysaccharide and a preparation method thereof. Meanwhile, the invention further discloses medical application of the polysaccharide in protection of alcoholic liver diseases. Compared with a single crude polysaccharide of toadstool and bolete, the toadstool and bolete compound crude polysaccharide disclosed by the invention has the advantages that the toadstool and bolete are compounded to carry out multiple reactions, for example, novel monosaccharide chains occur by virtue of re-bonding of hydrogen bonds, Van der Waals force andchemical bonds. The specific reaction is that phenomena such as number increase and mergence occur at the detection peak, so that a foundation is laid for achieving better effects compared with the single crude polysaccharide of toadstool and bolete for subsequent investigation of the alcoholic liver diseases. The prepared toadstool and bolete compound crude polysaccharide freeze-dried powder is safe, has no side effects, has an obvious health effect, can be taken for a long time, and has excellent market development prospects.

Description

technical field [0001] The invention provides a morel and boletus compound crude polysaccharide and a preparation method, and also discloses the medical use of the polysaccharide in protecting alcoholic liver disease, belonging to the technical field of traditional Chinese medicine and health food. Background technique [0002] The mortality rate of alcoholism is similar to the mortality rate of cancer and coronary heart disease, and it is one of the leading causes of death among young and middle-aged people; alcoholic liver disease usually occurs in those who drink excessively for many years. The longer the drinking time and the greater the amount of alcohol consumed, the greater the possibility of alcoholic liver disease. Heavy drinking over a short period of time can also lead to alcoholic hepatitis, which can even be life-threatening in extreme cases. Alcoholic liver disease is asymptomatic at the initial stage, but symptoms such as weight loss, loss of appetite, nausea...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K31/715A61P1/16A23L33/125
CPCA23V2002/00A61K31/715A23L33/125A61P1/16C08B37/0003A23V2200/30A23V2250/51
Inventor 王迪逯家辉刘燕隔滕利荣孟庆繁周毓麟王贞佐程瑛琨
Owner JILIN UNIV
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