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Cnp cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide

A technology for external preparations and cosmetics, which is applied in the fields of CNP cyclic peptides and drugs, external preparations and cosmetics containing the cyclic peptides, can solve the problems of long duration of effects and short therapeutic effects, and achieves rough skin improvement, excellent quick-acting properties, long relief effect

Pending Publication Date: 2019-02-15
IGISU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, in the case of rhinitis, steroids are often used, and there are many cases in which the therapeutic effect is short-lived compared with its side effects and the expected effect cannot be obtained. Long, and no side effects (Patent Documents 2 to 4)

Method used

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  • Cnp cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide
  • Cnp cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide
  • Cnp cyclic peptide, and medicine, external preparation and cosmetic each containing said cyclic peptide

Examples

Experimental program
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Embodiment

[0292] The present invention will be described in more detail through examples below. However, the present invention is not limited by these Examples.

[0293] 1. Manufacture of Cyclic Peptides

[0294]Firstly, a cyclic peptide formed by the amino acid sequence shown in formula I is synthesized.

[0295] Specifically, using a peptide synthesizer, amino acids were sequentially combined by a peptide solid-phase synthesis method to form a linear peptide consisting of 17 amino acids. Then, the protecting groups of the first Cys and the 17th Cys from the N-terminus were removed. After that, iodine (I 2 ) treatment to oxidatively form cysteine ​​bonds between amino acid residues to form cyclic peptides.

[0296] The obtained cyclic peptide-containing composition was purified by reverse-phase liquid high-speed chromatography (reverse-phase HPLC), and then freeze-dried to obtain a purified cyclic peptide in the form of white powder.

[0297] In addition, mass analysis of the obta...

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Abstract

The present invention addresses the problem of providing: a novel peptide which can exert the medicinal effect or efficacy thereof rapidly and has a long duration of remission; and a medicine and an external preparation, particularly a prophylactic or therapeutic agent for dermatitis, rough skin, rhinitis, alopecia or thinning hair, a hair growth agent, an anti-depilation agent, an antipruritic agent, a skin care product and the like, each of which contains the peptide. According to the present invention, the problem can be solved by providing a cyclic peptide comprising the amino acid sequence represented by formula I wherein the amino acid sequence does not contain a peptide bond other than peptide bonds formed between amino acid residues that constitute the amino acid sequence, or a derivative of the cyclic peptide, or a pharmaceutically acceptable salt of the cyclic peptide or the derivative.

Description

technical field [0001] The present invention relates to CNP cyclic peptide and medicines, external preparations and cosmetics containing the cyclic peptide. Background technique [0002] CNP (C-type natriuretic peptide: C-type natriuretic peptide), which is known as a human NP family, is not produced in the heart but is specifically produced in the brain, unlike ANP and CNP classified in the same family. In addition, it is known that compared with ANP and CNP, although the natriuretic effect and hypotensive effect are weak, the effect of increasing cyclic guanosine monophosphate (cGMP) in cells such as vascular smooth muscle cells is strong (Non-Patent Document 1) , for its physiological role, is thought to be responsible for actions other than maintaining homeostasis of body fluid volume and blood pressure. [0003] Regarding CNP, it is known that the constituent amino acids are highly conserved among individual species and there is little difference, and that the structur...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/54A61K8/64A61K9/06A61K9/10A61K9/107A61K9/12A61K9/14A61K9/20A61K38/00A61P3/00A61P3/04A61P7/10A61P9/04A61P9/10A61P9/12A61P11/02A61P17/00A61P17/04A61P17/14A61P29/00A61P37/00A61P43/00A61Q5/02A61Q19/10C07K7/08C07K14/575
CPCA61K38/00A61K8/64A61Q19/10A61K9/06A61K9/12C07K14/58A61Q5/00A61Q7/00A61Q17/04A61Q19/00A61Q19/005A61Q19/007A61Q19/02A61Q19/08A61K2800/10A61K47/10A61K9/08A61P17/10A61P17/06A61P17/14A61P17/00A61P11/02A61K9/0014A61K9/0043A61K38/10A61K9/10A61K9/107A61K9/14A61K9/20C07K7/08C07K7/54C07K14/575A61Q5/006A61Q5/008A61Q5/02A61Q19/008
Inventor 远藤京子远藤阳央莉
Owner IGISU
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