Method for preparing indigo naturalis

An indigo plant and plant technology, applied in the field of preparation of indigo plant, can solve the problems of poor product quality, influence on curative effect, time-consuming and labor-intensive, etc., and achieve the effects of shortening production cycle, reducing labor intensity and simple production process.

Active Publication Date: 2019-02-22
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Patent application number: CN201110152247.1, invention name: "a processing method of Qingdai", the yield of indigo in Qingdai obtained by this processing method is 1.8mg / g, and the yield of indirubin is 0.35mg / g, The yield mentioned therein is the mass mg of indigo and indirubin in crude indigo / the mass g of fresh leaves, but the obtained crude indigo contains a large amount of lime, and it must be purified by water to obtain Qingdai, which is time-consuming and labor-intensive. , and the content of indigo and indirubin in Qingdai processed by traditional methods is relatively low, and the product quality is not good, which affects the curative effect

Method used

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Examples

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Effect test

Embodiment 1

[0021] A kind of preparation method of Qingdai of the present invention, comprises the steps:

[0022] (1) Take the leaves or stems of Isatis indigo, Polygonaceae, or Isatis indigo, and cut the corresponding fresh leaves to 1-2 cm, and place them in a refrigerator with a temperature of 50-90 ° C. In hot water, the temperature of hot water is preferably 80°C, the mass ratio of hot water to fresh leaves is 8-15, the mass ratio is preferably 10, the hot water extraction is 15-120 minutes, the extraction time is preferably 30 minutes, and the leaf residue is filtered to obtain the filtrate . It should be noted that the lower limit of the hot water extraction time of 15 minutes can ensure that the substances in the fresh leaves are fully dissolved. As the extraction time increases, the substances in the fresh leaves will continue to dissolve. On the one hand, the continuous high temperature will affect the dissolved substances such as unstable degradation; on the other hand, the c...

Embodiment 2

[0027] A kind of preparation method of Qingdai of the present invention, comprises the steps:

[0028] (1) Take the leaves or stems of Isatis indigo, Polygonaceae, or Isatis indigo, and cut the corresponding fresh leaves to 1-2 cm, and place them in hot water at a temperature of 80°C , the mass ratio of hot water to fresh leaves was 10, extracted with hot water for 30 minutes, and filtered to remove leaf residue to obtain the filtrate;

[0029] (2) After passing through ozone in the filtrate for 10-300s, adding a mass concentration of 3% phosphoric acid solution for hydrolysis for 120min, in the present invention, the time for passing through ozone is preferably 60s, and the hydrolysis temperature is 80°C. After the hydrolysis is completed, a hydrolysis mixed liquid;

[0030] (3) Use 3% sodium hydroxide solution to adjust the pH value of the hydrolysis mixture to 7, discard the supernatant after standing for stratification, take the precipitate, wash until neutral, and dry to...

Embodiment 3

[0036] A kind of preparation method of Qingdai of the present invention, comprises the steps:

[0037] (1) Take the leaves or stems and leaves of the Acanthaceae plant S. indigo, the Polygonaceae plant Polygonum indigo, or the Cruciferous plant Isatis indigo, and cut the corresponding fresh leaves to 1-2 cm, and place them in a hot oven at a temperature of 60 ° C. In water, the mass ratio of hot water to fresh leaves is 10, extract with hot water for 30 minutes, filter to remove leaf residue, and obtain the filtrate;

[0038] (2) After passing ozone in the filtrate for 60s, add a hydrochloric acid solution with a mass concentration of 3% for hydrolysis for 120min, and the hydrolysis temperature is 80°C. After the hydrolysis is completed, a hydrolysis mixture is obtained;

[0039] (3) Adjust the pH value of the hydrolysis mixture to 7 with a potassium hydroxide solution of 3% mass concentration, discard the supernatant after standing for stratification, take the precipitate, wa...

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Abstract

The invention discloses a method for preparing indigo naturalis. The method comprises the following steps: selecting leaves or stem leaves of jacobinia suberecta baphicacanthus cusia, polygonaceae plant indigo or crucifer isatis tinctorial, extracting in hot water, and filtering to remove leave residues to obtain filtrate; adding an acid solution into the filtrate, and performing hydrolysis; adding an alkali solution to adjust the pH value of the solution to be 6-8 after hydrolysis is completed, standing, removing supernate to obtain precipitate, washing to be neutral, and drying to obtain theindigo naturalis. According to the preparation method, a new way for preparing indigo naturalis is provided, the influence of CaCO3 can be avoided, the labor intensity for preparing indigo naturaliscan be greatly reduced, and the production cycle can be shortened. By utilizing the preparation method, the content of indigo is 30.51-54.84 percent, the content of indirubin is 5.41-13.52 percent, the content of indigo is increased by 10-20 times that by a traditional processing method, and the content of indirubin is increased by 20-30 times that by the traditional processing method, and the quality of indigo naturalis products realizes qualitative leap.

Description

technical field [0001] The invention belongs to the field of processing and processing of traditional Chinese medicines, in particular to a preparation method of Qingdai. Background technique [0002] Indigo Daisy is the dry powder or pellet obtained by processing the leaves or stems of Baphicacanthus cusia (Nees) Bremek., Polygonum tinctorium Ait., or Isatis indigotica Fort. lumps or granules. The traditional processing of Indigo Naturalis mainly includes three steps: soaking, indigo beating, and water-flying refining. Active ingredients such as jade red. The traditional processing of Qingdai is usually done in a family workshop. The specific steps are to take fresh horse blue leaves or stems and leaves in a soaking fermentation tank, introduce appropriate river water, soak and ferment for 1 to 2 days, and remove the residue when the liquid turns dirty green. Put in fresh lime milk, stir well, let it stand for 1-2 days, discard the supernatant, collect the substrate sedi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K36/315A61K36/195A61K127/00A61K135/00
CPCA61K36/195A61K36/315A61K36/704A61K2236/331A61K2236/53
Inventor 徐先祥刁勇周心怡
Owner HUAQIAO UNIVERSITY
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