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Gold nanometer set square-titanium dioxide core-shell nanohybrid and preparation method as well as application thereof

A nanocomposite and titanium dioxide technology, applied in the fields of biomedicine and material chemistry, can solve the problems of relatively little research on photothermal therapy, and achieve the ability to kill cancer cells, good photothermal effect, and good photothermal conversion effect Effect

Inactive Publication Date: 2019-02-22
HUANGHE S & T COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are relatively few studies on the photothermal treatment of gold nanocrystals in the second infrared window.

Method used

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  • Gold nanometer set square-titanium dioxide core-shell nanohybrid and preparation method as well as application thereof
  • Gold nanometer set square-titanium dioxide core-shell nanohybrid and preparation method as well as application thereof
  • Gold nanometer set square-titanium dioxide core-shell nanohybrid and preparation method as well as application thereof

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Embodiment 1

[0029] A kind of preparation method of gold nano triangular plate-titanium dioxide core-shell nanocomposite:

[0030] 1. Preparation of Gold Nanotriangular Plate Seeds

[0031] 1 mL of 0.01M chloroauric acid (HAuCl 4 ) solution and 1mL 0.01M trisodium citrate solution were sequentially added to 36mL of ultrapure water, and 1mL of freshly prepared 0.01M sodium borohydride solution (NaBH 4 ), stirred vigorously for 30s, and then stood at room temperature for 2h.

[0032] 2. Preparation of Gold Nanotriangular Plate Growth Solution

[0033] Growth Solution 1 and Growth Solution 2 are the exact same solution. The specific preparation is as follows, first prepare 9 mL of 0.05M cetyltrimethylammonium bromide solution (CTAB), and then add 0.01M 250 μL HAuCl to it sequentially 4 , 0.1M 50 μL sodium hydroxide solution (NaOH), 0.01M 50 μL potassium iodide solution (KI) and 0.1M 50 μL ascorbic acid solution (AA), mix well. The solution color eventually became colorless.

[0034] Gro...

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Abstract

The invention relates to a gold nanometer set square-titanium dioxide core-shell nanohybrid and a preparation method as well as an application thereof, and belongs to the technical field of biomedicine and material chemistry. The preparation method comprises the following steps that (1) a mother liquor of a gold nanometer set square is centrifuged, and dispersed in ultrapure water of which the volume is equal to the volume of the mother liquor to obtain a gold nanometer set square solution; (2) the gold nanometer set square solution is dropwise added into a sodium polystyrene sulfonate solution, stirring is carried out for 8-12 hours, centrifuging is carried out, and then the obtained solid is dispersed in the ultrapure water to obtain a gold nanometer set square-sodium polystyrene sulfonate solution; and (3) titanium trichloride and the ultrapure water are mixed, a sodium bicarbonate solution is dropwise added when stirring is carried out, then the gold nanometer set square-sodium polystyrene sulfonate solution is added, mixing and stirring are carried out for 0.5-1.5 hours, and finally the gold nanometer set square-titanium dioxide core-shell nanohybrid is obtained. The culture of the gold nanometer set square-titanium dioxide core-shell nanohybrid and cancer cells is carried out and illumination is carried out, and then the ability of the gold nanometer set square-titanium dioxide core-shell nanohybrid to well kill the cancer cells is demonstrated; and the nano-structure shows a good application prospect in cancer treatment.

Description

technical field [0001] The invention belongs to the technical fields of biomedicine and material chemistry, and in particular relates to a gold nano triangular plate-titanium dioxide core-shell nanocomposite, its preparation method and application. Background technique [0002] Photothermal therapy, which refers to providing high-temperature local heating to remove tumors when lasers are irradiated to tumor sites, has great application potential in cancer treatment. Near-infrared light is widely used in photothermal therapy because it can effectively pass through biological tissues and accurately locate tumor sites. In the near-infrared region, there are two infrared windows, the wavelength range of the first infrared window is 650nm-950nm, and the wavelength range of the second infrared window is 1000nm-1350nm. Although the penetration depth of traditional lasers in the first infrared window range is greatly improved compared with visible light, it is still unsatisfactory ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02
CPCB22F1/0553B22F1/054B22F1/145B22F1/16
Inventor 高凤丽张守仁魏士礼何广莉杨保成
Owner HUANGHE S & T COLLEGE
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