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1,3-O-diferuloyl-2-methoxypropanediol as well as preparation method and application thereof

A methanol and dichloromethane technology, applied in the field of 1,3-O-diferulate-2-methoxypropanediol and its preparation and application, can solve the problem of rare non-alkaloid compounds and achieve strong Inhibitory effect, simple preparation method, and wide-ranging sources

Active Publication Date: 2019-02-22
新疆维吾尔自治区中药民族药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The medicinal effect of Fritillaria Ili is mainly derived from the steroidal alkaloid compounds, but the reports of its non-alkaloid compounds are relatively rare, so the development and utilization of It is of great significance for the development and utilization of Ili Fritillaria's non-alkaloid monomer compounds to further explore its potential medicinal value, and to determine and characterize the structure and physical and chemical properties of its monomer compounds

Method used

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  • 1,3-O-diferuloyl-2-methoxypropanediol as well as preparation method and application thereof
  • 1,3-O-diferuloyl-2-methoxypropanediol as well as preparation method and application thereof
  • 1,3-O-diferuloyl-2-methoxypropanediol as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: The chemical structural formula of the 1,3-O-diferuloyl-2-methoxypropanediol is

[0022]

[0023] 1,3-O-diferuloyl-2-methoxypropanediol of the present invention carries out proton nuclear magnetic resonance spectrum ( 1 H-NMR) and carbon nuclear magnetic resonance ( 13 C-APT) analysis, 1 H-NMR spectrum as figure 1 as shown, 13 C-APT spectrum as figure 2 shown, yes figure 1 with figure 2 To analyze the spectrum, the figure 1 with figure 2 The peaks are assigned, figure 1 with figure 2 The peak assignments are shown in Table 1. pass figure 1 , figure 2 From the data in Table 1, it can be seen that the chemical structural formula of 1,3-O-diferuloyl-2-methoxypropanediol of the present invention is shown in the above examples, and it is easily soluble in chloroform and methanol.

Embodiment 2

[0024] Example 2: As an optimization of the above example, it is obtained according to the following method: the first step, after crushing the root of Fritillaria Ili, add methanol, soak it at room temperature for 3 hours to 4 hours, and heat it at 50°C to 60°C Heating and reflux extracting 3 times under the conditions, each time for 1 hour to 3 hours, combining each reflux extract and recovering and concentrating under reduced pressure to obtain the total extract of Fritillaria Ili; the second step is to disperse the total extract of Fritillaria Ili with water After forming a suspension, extract with petroleum ether, chloroform, and ethyl acetate in sequence, and concentrate the extract to obtain the chloroform part extract; the third step, take the chloroform part extract and separate it by gradient elution with silica gel column chromatography to obtain 11 Fraction, wherein, the silica gel column chromatography gradient eluent comprises sherwood oil, methylene dichloride an...

Embodiment 3

[0025] Example 3: As an optimization of the above example, in the first step, add 8ml to 10ml of methanol per 1g of the root of Fritillaria Ili.

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Abstract

The invention relates to the technical field of Fritillaria pallidiflora Schrenk separation and purification, in particular to 1,3-O-diferuloyl-2-methoxypropanediol as well as a preparation method andapplication thereof. The invention discloses the compound 1,3-O-diferuloyl-2-methoxypropanediol and the preparation method thereof for the first time. According to the 1,3-O-diferuloyl-2-methoxypropanediol as well as the preparation method and application thereof, the 1,3-O-diferuloyl-2-methoxypropanediol is obtained by carrying out extraction and separation on Fritillaria pallidiflora Schrenk, the preparation method is simple and convenient to use, sources are extensive, the compound has a relatively strong inhibition effect on HepG-2 cells and HeLa cells, and therefore the compound can be applied in preparation of drugs for preventing tumors, anti-tumor drugs and health care products for preventing and treating the tumors.

Description

technical field [0001] The invention relates to the technical field of Ili Fritillaria separation and purification, and relates to 1,3-O-diferuloyl-2-methoxypropanediol and its preparation method and application. 1,3-O-diferuloyl-2-methoxypropanediol It is the abbreviation of the 1,3-O-diferuloyl-2-methoxypropanediol. Background technique [0002] Fritillaria pallidiflora Schrenk is a plant of the genus Fritillaria of the Liliaceae family Liliaceae. It is mainly distributed in the Ili River Basin of Xinjiang, and is mainly produced in Yining, Zhaosu, Suiding, Huocheng, Nileke, Bole, etc. in the northwest of Xinjiang. land. Its bulbs are used as medicine, taste bitter, sweet, slightly cool, and return to the lungs and heart meridians. Clinically, it has the effects of antitussive, expectorant, and asthmatics. Its sedative and hypoxia-resistant effects are very beneficial to asthmatic patients. Treat respiratory infections. Yili Fritillaria is a specialty medicine in Xinjia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/734C07C67/48C07C67/54C07C67/56A61K31/216A61P35/00A23L33/105
CPCA23V2002/00A61K31/216A23L33/105A61P35/00C07C67/48C07C67/54C07C67/56C07C69/734A23V2250/21A23V2250/2132A23V2200/308
Inventor 石磊岭马国需魏鸿雁马晓玲阿勒腾图娅陈刚王凯郭雄飞
Owner 新疆维吾尔自治区中药民族药研究所
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