Chlorine-modified hyperbranched polyglycidyl ether derivatives, preparation method and use thereof
A technology of glycidyl ether and hyperbranched polymer, which is applied in the field of biomedicine, can solve problems such as undiscovered, and achieve the effect of improving curative effect and high yield
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Embodiment 1
[0049] A chemical structural formula of a hyperbranched polyglycidyl ether derivative modified by chlorin is shown in formula (I):
[0050]
[0051] The preparation method of the chlorin-modified hyperbranched polyglycidyl ether derivative as a drug carrier comprises the following steps:
[0052] (1) Add 2.68g TMP to 0.42g potassium methoxide solution, heat to melt, remove methanol under reduced pressure, add 10mL glycidol dropwise at 95°C, the reaction time is ≥12h, the reaction product is precipitated twice with acetone, dried to obtain HPG (transparent viscous liquid);
[0053] (2) Weighing 1.0175g of HPG (molecular weight 2470, assuming 0.0165mol of -OH) is placed in a single-necked flask, and dried overnight in a vacuum oven at 80°C to remove a small amount of water in the HPG; take it out while it is hot, and use The anti-mouth rubber plug is sealed, and after cooling, it is installed on the double-row pipe, and the double-row pipe is used for operation. 2 Heat unde...
Embodiment 2
[0059] An embodiment of the preparation method of the chlorin-modified hyperbranched polyglycidyl ether derivative represented by formula (I) of the present invention, the preparation method described in this embodiment comprises the following steps:
[0060] (1) Add 4.02g TMP to 0.63g potassium methoxide solution, heat to melt, remove methanol under reduced pressure, add 15mL glycidol dropwise at 95°C, the reaction time is ≥12h, the reaction product is precipitated twice with acetone, dried to obtain HPG (transparent viscous liquid);
[0061] (2), HPG weighing 1.5262g is placed in a single-necked flask, and dried overnight in a vacuum oven at 80°C to remove a small amount of water in the HPG; take it out while it is hot, seal it with a reverse rubber stopper, and install it in the On the double row pipe, operate with double row pipe, in N 2 Heat under the atmosphere to remove a small amount of water in the bottle. After cooling, draw 60mL DMF with a syringe, pour it into the...
Embodiment 3
[0067] An embodiment of the preparation method of the chlorin-modified hyperbranched polyglycidyl ether derivative represented by formula (I) of the present invention, the preparation method described in this embodiment includes the following steps:
[0068](1) Add 5.36g of trimethylolpropane (TMP) to 0.84g of potassium methoxide solution, heat and melt, remove methanol under reduced pressure, add 20mL of glycidol dropwise at 95°C, the reaction time is ≥12h, and the reaction product is precipitated with acetone Twice, dry to obtain HPG (transparent viscous liquid);
[0069] (2) Weighing 2.035 HPG (molecular weight 2470, assuming 0.0330mol of -OH) is placed in a single-necked flask, and dried overnight in a vacuum oven at 80°C to remove a small amount of water in the HPG; The mouth rubber plug is sealed. After cooling, it is installed on the double-row pipe, and the double-row pipe is used for operation. 2 Heat under the atmosphere to remove a small amount of water in the bott...
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