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Preparation method for dendritic nano silicon particle

A nano-silicon and dendritic technology, applied in the field of preparation of dendritic nano-silicon particles, can solve the problems of affecting product safety, difficulty in scaling up production and manufacturing, etc., and achieve the effects of easy expansion of production, low production cost and good dispersibility.

Inactive Publication Date: 2019-03-01
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is still a huge challenge to use these methods to conveniently prepare dendritic nano-silicon particles with different particle sizes or shapes.
Some methods use a large amount of organic solvents, which not only affects the safety of the product, but also creates difficulties for subsequent scale-up production

Method used

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  • Preparation method for dendritic nano silicon particle
  • Preparation method for dendritic nano silicon particle
  • Preparation method for dendritic nano silicon particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Add 1.5 g of cetyltrimethylammonium bromide and 0.7 g of sodium octanoate (1:1 molar ratio) into 100 ml of deionized water, stir and dissolve at 95°C for 30 minutes, add 10 ml of ethyl orthosilicate Stir the reaction for 2 hours, centrifuge at 6000 rpm for 10 minutes, discard the supernatant; disperse and centrifuge with 30 ml of water or ethanol, repeat washing 2-3 times, and dry to obtain dendritic nano-silicon with a particle size of 219±24 nm particles ( figure 1 ).

Embodiment 2

[0035] Add 1.5 g of cetyltrimethylammonium bromide and 0.7 g of sodium octanoate (1:1 molar ratio) into 100 ml of deionized water, stir and dissolve at 95°C for 30 minutes, add 14 ml of ethyl orthosilicate Stir the reaction for 2 hours, centrifuge at 6000 rpm for 10 minutes, discard the supernatant; disperse and centrifuge with 30 ml of water or ethanol, repeat washing 2-3 times, and dry to obtain dendritic nano-silicon with a particle size of 275±20 nm particles ( figure 2 ).

Embodiment 3

[0037] Add 1.5 g of cetyltrimethylammonium bromide and 0.35 g of sodium octanoate (molar ratio 1:0.5) into 100 ml of deionized water, stir and dissolve at 95°C for 30 minutes, add 14 ml of ethyl orthosilicate and stir After 8 hours of reaction, centrifuge at 6000 rpm for 10 minutes, discard the supernatant; disperse and centrifuge with 30 ml of water or ethanol, and wash repeatedly 2-3 times to obtain dendritic nano-silicon particles with a particle size of 220±9 nm ( image 3 ).

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Abstract

The invention belongs to the field of new methods for preparing a medical nano preparation auxiliary material, and particularly relates to a preparation method for a dendritic nano silicon particle. The method comprises the following steps: using hexadecyl trimethyl ammonium halide, silicate ester, fatty acid salt and deionized water as reaction raw materials, and synthesizing the dendritic nano silicon particle of which a surface structure is a central radial pore structure. The preparation method is moderate in condition, environment-friendly, and easy to amplification production. An obtained product is stable in structure, good in dispersibility, and can be used as a carrier of a biomacromolecule or a drug, a catalyst molecule and the like.

Description

technical field [0001] The invention belongs to the field of new methods for preparing medical nano-preparation auxiliary materials, and in particular relates to a method for preparing dendritic nano-silicon particles. Background technique [0002] Nano drug carrier has important application value and has become a hot research field. Mesoporous silicon nanomaterials (particle size less than 500 nm) have many technical advantages, such as high specific surface area and pore volume, good colloidal stability, excellent biocompatibility, etc. In addition, the particle size, mesopore diameter and morphology can be adjusted, and the surface and interior of the particles can be chemically modified to make them functional. Engineering, drug carrier, etc.) have extensive and important application prospects. [0003] The good adsorption and loading capacity of mesoporous nanosilica materials make them candidates for drug carriers. Common mesoporous nano-silicon materials, such as M...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B33/021B82Y30/00B82Y40/00A61K47/04A61K47/69
CPCA61K47/02A61K47/6949B82Y30/00B82Y40/00C01B33/021
Inventor 荀哲关一夫
Owner 中国医科大学
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